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. 2022 Aug 3;19(193):20220364. doi: 10.1098/rsif.2022.0364

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© 2022 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 2. — Schematic diagram, approximately to scale, showing hypothesized relationships between the hyaluronan-aggrecan complex and collagen fibrils. Aggrecans associate via their G1 globular domain along the HA molecule stabilized by LP. Assuming there is rotational flexibility, they can lie either side of the HA. This assembly then can lie along a portion of the collagen fibril leaving a gap between CS-regions of adjacent aggrecans of approximately the same dimensions as the fibril diameter. The KS-region of the aggrecan is localized to the gap region of the collagen and the KS chains all point in the same direction. The CS-regions (CS1 and CS2) then protrude into the inter-fibrillar space and have been shown extended although their conformation is unknown.