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. 2022 Jul 20;23(8):e54558. doi: 10.15252/embr.202154558

Figure 1. Deregulated neutrophil response in human tissue samples obtained from diabetic foot ulcers.

Figure 1

  • A
    Enriched GO processes from human skin acute day 3 wounds compared to human DFU demonstrates processes involved in neutrophil function to be deregulated in DFUs compared to acute wounds.
  • B
    Neutrophil gene signature comparing human skin acute day 3 wounds to human DFUs demonstrating decreased presence of neutrophils in human DFUs.
  • C
    qPCR validations of neutrophil genes. n = 7 DFUs and n = 3 skin acute day 3 wounds. **P < 0.01 (two‐tailed unpaired Student's t‐test). Data presented as mean ± SD.
  • D
    Ingenuity Pathway Analysis of predicted network shows activation of cell viability of neutrophils and inhibition of cell death of neutrophils in human skin wounds compared to activation of cell death of neutrophils in human DFUs.