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. 2022 Jul 18;23(8):e55393. doi: 10.15252/embr.202255393

Figure 3. Virus receptor binding.

Figure 3

Virus receptors and primary antigens are detailed. For variola virus, the structure of the small molecule receptor chondroitin sulfate is shown. For SARS‐CoV‐2, the reversible conformational change between RBD‐accessible and inaccessible orientations (impacted by the residue in site S614) of the trimeric surface structure is highlighted. For H1N1, the structure of the small molecule receptor sialic acid is shown, with the host‐specific galactose linkages (human, α2,6Gal; waterfowl α2,3) emphasized. A public domain image for chondroitin sulfate was used: https://en.wikipedia.org/wiki/Chondroitin_sulfate.