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. 2022 Jul 26;2022:3695848. doi: 10.1155/2022/3695848

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Copyright © 2022 Zixiang Geng et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Differences in the microRNA carried by exosomes derived from amniotic fluid stem cells (AFSCs) and exosomes derived from nonstem cells. (a) Morphology of the CD44+/CD105+ subpopulation isolated from human primary amniotic fluid. Original magnification, 200x. (b) Phenotype of HuAFSC-exosomes detected by electron microscopy. Scale bar: 100 nm. (c) The size of HuAFSC-exosomes and HuFCs-exosomes was assessed by nanoFCM. (d) Western blot analysis of exosome marker expression in HuAFSC-exosomes and HuFCs-exosomes. (e) miRNA-Seq results revealed several genes that showed different expression levels between the HuAFSC-exosomes and HuFCs-exosomes. (f) Volcano plot of significant differentially expressed miRNA with a fold-change [log2(HuAFSCs/HuFCs)] > −2 or < ˗3, P < 0.05; green and red colors represent downregulated and upregulated expressions, respectively.