Table 5.

Multi-level Models: Longitudinal Associations of RDoC Constructs at Age 7 with HBQ and DISC at Age 13

Outcome HBQ	Predictors	Estimate	s.e.	p-value	FDR p-value	Outcome DISC	Predictors	Estimate	s.e.	p-value	FDR p-value
Depression	Reward Responsiveness	0.016	0.017	0.3572	0.5384	Depression	Reward Responsiveness	0.055	0.084	0.5140	0.6976
	Frustrative Nonreward	0.021	0.018	0.2594	0.4808		Frustrative Nonreward	0.171	0.084	0.0412	0.1648
	Loss	0.045	0.021	0.0317	0.1417		Loss	0.220	0.091	0.0161	0.0941
	Fear	0.003	0.016	0.8392	0.9315		Fear	−0.033	0.077	0.6722	0.8240
Overanxiousness	Reward Responsiveness	−0.002	0.020	0.9058	0.9809	Generalized Anxiety	Reward Responsiveness	−0.022	0.092	0.8145	0.9280
	Frustrative Nonreward	0.026	0.022	0.2396	0.4808		Frustrative Nonreward	−0.009	0.097	0.9293	0.9809
	Loss	0.037	0.025	0.1431	0.3468		Loss	0.192	0.104	0.0650	0.2352
	Fear	0.016	0.019	0.4158	0.5951		Fear	0.057	0.085	0.5023	0.6941
Separation Anxiety	Reward Responsiveness	0.017	0.017	0.3086	0.5099	Separation Anxiety	Reward Responsiveness	0.116	0.141	0.4122	0.5951
	Frustrative Nonreward	0.019	0.018	0.2875	0.5081		Frustrative Nonreward	0.131	0.143	0.3613	0.5384
	Loss	0.027	0.020	0.1739	0.3737		Loss	0.255	0.152	0.0930	0.3213
	Fear	0.012	0.016	0.4228	0.5951		Fear	−0.030	0.129	0.8181	0.9280
Social Anxiety	Reward Responsiveness	−0.064	0.025	0.0110	0.0697	Social Anxiety	Reward Responsiveness	−0.311	0.140	0.0261	0.1322
	Frustrative Nonreward	−0.041	0.027	0.1228	0.3369		Frustrative Nonreward	−0.209	0.155	0.1770	0.3737
	Loss	0.046	0.031	0.1315	0.3369		Loss	0.235	0.161	0.1460	0.3468
	Fear	0.032	0.023	0.1718	0.3737		Fear	0.121	0.132	0.3613	0.5384
Inhibition	Reward Responsiveness	−0.072	0.026	0.0051	0.0388*	Specific Phobia	Reward Responsiveness	−0.125	0.116	0.2821	0.5081
	Frustrative Nonreward	−0.100	0.028	0.0003	0.0076**		Frustrative Nonreward	0.113	0.119	0.3407	0.5384
	Loss	0.029	0.031	0.3527	0.5384		Loss	0.354	0.124	0.0043	0.0363*
	Fear	0.025	0.024	0.3066	0.5099		Fear	0.002	0.109	0.9853	0.9940
Impulsivity	Reward Responsiveness	0.038	0.024	0.1180	0.3369	ADHD	Reward Responsiveness	0.146	0.096	0.1281	0.3369
	Frustrative Nonreward	0.116	0.026	<.0001	<.0001***		Frustrative Nonreward	0.208	0.094	0.0281	0.1335
	Loss	0.069	0.030	0.0209	0.1135		Loss	0.294	0.102	0.0041	0.0363*
	Fear	0.014	0.023	0.5526	0.7241		Fear	−0.005	0.090	0.9537	0.9929
Inattention	Reward Responsiveness	0.032	0.029	0.2594	0.4808	Conduct Disorder	Reward Responsiveness	0.194	0.126	0.1235	0.3369
	Frustrative Nonreward	0.093	0.031	0.0026	0.0363*		Frustrative Nonreward	0.147	0.127	0.2491	0.4808
	Loss	0.110	0.035	0.0018	0.0342*		Loss	0.211	0.141	0.1330	0.3369
	Fear	0.000	0.027	0.9940	0.9940		Fear	0.023	0.120	0.8457	0.9315
Conduct Disorder	Reward Responsiveness	0.004	0.009	0.6074	0.7568	Oppositional Defiant	Reward Responsiveness	0.073	0.045	0.1096	0.3369
	Frustrative Nonreward	0.027	0.009	0.0034	0.0363*		Frustrative Nonreward	0.067	0.047	0.1526	0.3514
	Loss	0.020	0.011	0.0590	0.2242		Loss	0.106	0.052	0.0409	0.1648
	Fear	0.004	0.008	0.5862	0.7425		Fear	0.068	0.042	0.1041	0.3369
Opposition	Reward Responsiveness	0.029	0.026	0.2574	0.4808
	Frustrative Nonreward	0.080	0.028	0.0041	0.0363*
	Loss	0.033	0.032	0.3007	0.5099
	Fear	0.001	0.024	0.9799	0.9940
Overt Aggression	Reward Responsiveness	0.006	0.015	0.6988	0.8430
	Frustrative Nonreward	0.061	0.017	0.0003	0.0076**
	Loss	0.011	0.019	0.5648	0.7275
	Fear	−0.001	0.015	0.9229	0.9809
Relational Aggression	Reward Responsiveness	0.003	0.014	0.8121	0.9280
	Frustrative Nonreward	0.041	0.015	0.0076	0.0525
	Loss	0.011	0.017	0.5363	0.7151
	Fear	−0.004	0.013	0.7435	0.8829

Note. HBQ: MacArthur Health and Behavior Questionnaire; average of mother and father report. DISC: Diagnostic Interview Schedule for Children-IV symptom counts; primary caregiver report. FDR: False Discovery Rate.

^*p < .05,

^**p <.01,

^***p < .001.

Significance reported only for FDR p-values.