Table 2.
Cox proportional hazards multivariable analysis of factor association with OS among FL patients with 1 or more TP53 mutations
| Parameter* | Full model (N = 237 with 219 events) | Reduced model | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | Individual P | Overall P | HR (95% CI) | Individual P | Overall P | |||||||||||
| Age, y, continuous | 1.01 (0.99, 1.02) | .3655 | .3655 | |||||||||||||
| Cytogenetic risk group | ||||||||||||||||
| Intermediate/favorable (N = 213; 89.9%) vs adverse (N = 24; 10.1%) | 0.43 (0.24, 0.77) | .0046 | .0046 | 0.45 (0.27, 0.74) | .0018 | .0018 | ||||||||||
| Allo-SCT † | ||||||||||||||||
| Yes (N = 23; 9.7%) vs no (N = 214; 90.3%) | 0.54 (0.31, 0.95) | .0313 | .0313 | 0.49 (0.30, 0.81) | .0052 | .0052 | ||||||||||
| TP53 CN | ||||||||||||||||
| Loss (N = 113; 64.2%) vs intact (N = 63; 35.8%) | 0.98 (0.67, 1.44) | .9191 | .5932 | |||||||||||||
| TP53 mutation | ||||||||||||||||
| >1 (N = 59; 24.9%) vs = 1 (N = 178; 75.1%) | 1.81 (1.30, 2.52) | .0004 | .0004 | 1.78 (1.30, 2.45) | .0004 | .0004 | ||||||||||
| TP53 VAF | ||||||||||||||||
| >40% (N = 130; 54.8%) vs ≤40% (N = 107; 45.2%) | 1.75 (1.32, 2.32) | .0001 | .0001 | 1.71 (1.29, 2.26) | .0002 | .0002 | ||||||||||
*
N = 237 except for allo-SCT, N = 176.
†
Analyzed as a time-dependent covariate.
Boldface highlights significant P values.