Table 1.
Different types of immune effectors included in the study
| Neo marker gene | TGF-β DNR | CAR/cytokine | CAR | iC9 | |
|---|---|---|---|---|---|
| Auto-VSTs | + | + | |||
| Donor VSTs | + | + | + | ||
| Donor allodepleted ATCs | + | ||||
| Auto ATCs | + | + | + | ||
| PA317* | + | ||||
| PG13† | + | + | + | + |
allo, allogeneic; ATC, activated T cell; auto, autologous; DNR, dominant-negative receptor; iC9, inducible caspase 9.
*
PA317: amphitropic retrovirus packaging cell line was used for auto-VSTs and donor VSTs (obtained by Genetic Therapy Inc).
†
PG13: murine embryonic fibroblastic PG13 packaging cell lines (obtained from ATCC; #CRL-10686) were used for all other GRV-IEC types.