Table 4.

Association of MRI measures with cognitive domains among EDIC participants (n = 415)

	Immediate memory				Delayed recall				Psychomotor andmental efficiency
	β	SE	t	P	β	SE	t	P	β	SE	t	P
TBV (per 10 cm3)	0.009	0.012	0.75	0.4513	0.013	0.014	0.91	0.3640	0.062	0.014	4.40	<0.0001
GMV (per 10 cm3)	0.031	0.012	2.53	0.0117	0.028	0.014	2.00	0.0460	0.048	0.015	3.30	0.0011
WMV (per 10 cm3)	−0.029	0.014	−2.02	0.0445	−0.020	0.017	−1.20	0.2309	0.022	0.017	1.26	0.2073
Ventricle volume (per 10 cm3)	−0.028	0.028	−1.02	0.3092	−0.017	0.032	−0.55	0.5824	−0.159	0.032	−4.97	<0.0001
Subarachnoid CSF volume (per 10 cm3)	−0.004	0.013	−0.34	0.7367	−0.011	0.015	−0.73	0.4688	−0.036	0.015	−2.36	0.0186
Hippocampus volume (per 1 cm3)	0.094	0.068	1.37	0.1703	0.055	0.078	0.70	0.4829	0.275	0.080	3.42	0.0007
WMH asinh volume (per 1 cm3)*	−0.020	0.060	−0.33	0.7439	−0.004	0.070	−0.06	0.9496	−0.228	0.069	−3.30	0.0011
Total white matter mean FA (per 0.01 unit)†	0.014	0.020	0.68	0.4957	0.019	0.023	0.81	0.4161	0.084	0.023	3.57	0.0004

Data are β-coefficients, SEs, t values, and P values from individual linear regression models evaluating the association of each MRI measure (independent) with each cognitive domain (dependent), with adjustment for ICV, age, sex, years of education, and scanner. β estimates are equal to the slope of the association (e.g., increase or decrease in cognitive domain for every unit change in the covariate). The signed t value corresponds to the magnitude and directionality of the association.

^*WMH was assessed in N = 380 EDIC participants; an inverse hyperbolic sine transformation was used to normalize the distribution (asinh).

^†Total white matter mean FA was assessed in N = 362 EDIC participants and was not adjusted for ICV.