Table 2.

CpGs associated with maternal glycemic index or glycemic load in the full group and stratified by maternal weight status

CpG	Chr	Position#	Nearest gene	Polymorphic	mQTL	Effect*	SE*	P value	Dir†	I 2
Glycemic index—all mothers (n = 2,003)
cg21301148	14	23878195	MYH6	Yes	No	0.099	0.019	1.00E−07	+++	0
Glycemic load—all mothers (n = 2,003)
cg09874107	3	184870896	C3orf70	No	No	0.002	0.000	7.50E−08	+++	67.6
cg27528695	1	109643479	SCARNA2	Yes	Yes	0.010	0.002	9.74E−08	+++	0
Glycemic index—mothers with normal weight (n = 1,509)
cg02079551	10	107023377	SORCS3	Yes	No	−0.085	0.015	1.38E−08	−−−	0
cg21301148	14	23878195	MYH6	Yes	no	0.120	0.021	1.78E−08	−−−	0
Glycemic index—mothers with overweight or obesity (n = 463)
cg18202627	2	200776533	C2orf69	No	No	−0.093	0.012	7.96E−15	−−−	0
cg16169361	8	8751409	MFHAS1	Yes	No	−0.101	0.016	1.19E−10	−−−	24.4
cg24458009	12	47472775	AMIGO2	Yes	Yes	−0.211	0.033	1.22E−10	−−−	72
cg18290075	3	153840477	ARHGEF26	No	Yes	−0.099	0.016	2.52E−10	−−−	54.2
cg25832796	14	24038103	JPH4	Yes	Yes	−0.254	0.041	4.09E−10	−−+	94.8
cg12972275	4	122722461	EXOSC9	Yes	No	−0.047	0.008	4.83E−10	−−−	48.6
cg18211447	14	102771717	MOK	No	No	−0.117	0.019	6.57E−10	−−−	89
cg04351062	12	24717058	SOX5	No	Yes	0.089	0.015	1.30E−09	++−	81.8
cg01078248	7	123197661	NDUFA5	No	No	−0.077	0.013	1.31E−09	−−+	74.8
cg06591466	14	96505869	C14orf132	No	No	−0.107	0.018	2.05E−09	−−+	74.8
cg26474288	3	98451287	ST3GAL6-AS1	No	No	−0.108	0.019	1.28E−08	−−−	0
cg24688926	19	6737877	GPR108	No	No	−0.074	0.013	1.41E−08	−−−	83
cg00006032	14	66974439	GPHN	No	No	−0.126	0.022	1.41E−08	−−+	69.3
cg06171242	6	24667490	ACOT13	No	No	−0.061	0.011	1.52E−08	−−−	49.5
cg13445358	12	53661749	ESPL1	Yes	No	−0.062	0.011	1.96E−08	−−+	0
cg17582259	17	33288330	CCT6B	No	No	−0.094	0.017	1.97E−08	−−+	55.3
cg20927656	12	7863229	DPPA3	Yes	Yes	1.355	0.242	2.12E−08	+?+	61.3
cg02725014	5	78809520	HOMER1	No	No	−0.113	0.02	2.30E−08	−−−	0
cg13721560	2	44222568	LRPPRC	No	No	−0.068	0.012	2.83E−08	−−+	56.5
cg13358349	10	71211210	TSPAN15	Yes	No	−0.11	0.02	2.96E−08	−−−	28.9
cg16604801	17	2718310	RAP1GAP2	No	No	−0.071	0.013	3.34E−08	−−−	71.1
cg13740771	20	3026904	MRPS26	No	No	−0.113	0.021	4.36E−08	−−−	0.5
cg16031283	22	20861701	MED15	No	No	−0.092	0.017	5.79E−08	−−−	46.3
cg00367659	17	33288544	ZNF830	No	No	−0.132	0.024	6.40E−08	−−+	40.5
cg26985201	3	197517876	LRCH3	No	No	−0.085	0.016	6.75E−08	−−−	55.4
cg15225042	19	13044582	FARSA	No	No	−0.077	0.014	6.83E−08	−−+	70.5
cg23347399	5	140766911	PCDHGA1	No	Yes	0.4	0.075	8.30E−08	+++	17.8
cg27193519	16	4714443	MGRN1	Yes	Yes	0.292	0.055	8.58E−08	+++	93.9
cg24340911	17	5342028	C1QBP	No	No	−0.077	0.014	1.06E−07	−−−	71.5
cg07254608	8	41997973	AP3M2	No	No	−0.129	0.024	1.07E−07	−−−	11.5
cg09668030	1	27852173	AHDC1	No	No	0.260	0.049	1.18E−07	++?	8.7
Glycemic load—mothers with normal weight (n = 1,509)
cg02920421	1	32572534	KPNA6	Yes	No	−0.014	0.002	1.99E−08	+−−	74.3
cg26729101	16	229500	HBQ1	Yes	No	−0.007	0.001	1.01E−07	+−−	56.6
Glycemic load—mothers with overweight or obesity (n = 463)
cg03223949	20	60397915	CDH4	Yes	Yes	−0.013	0.002	1.15E−08	−−+	42.7
cg23345004	18	44526430	KATNAL2	No	Yes	−0.035	0.006	2.81E−08	−−−	0
cg25044186	6	170494475	LOC154449	Yes	Yes	−0.013	0.002	8.99E−08	−−−	0
cg09480470	12	124556975	ZNF664-RFLNA	No	Yes	−0.084	0.016	9.74E−08	−?−	0

Chr, chromosome; Dir, direction of association for each cohort.

^#Position is annotated using hg19.

^*Effect size and SE are presented as percentage change in DNA methylation per 1-point increase in the glycemic index or load.

^†Cohorts are ordered as ALSPAC, Generation R, and INMA.