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. 2022 May;10(9):526. doi: 10.21037/atm-22-1076

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2022 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

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Morphological and histopathological profiles of NMOs and NPCOs. (A) The morphology of NMOs and NPCOs under light microscopy; (B) H&E staining results for NMOs and their corresponding tissues; (C) H&E staining results for NPCOs and their corresponding NPC tissues; (D) the IHC results for CK7 in NMOs and NPCOs; (E) EBER ISH results for NPCOs and their corresponding NPC tissues. 40× magnification used for organoid models and 20× for tissues. NMO, nasal mucosa organoid; NPCO, nasopharyngeal carcinoma organoid; H&E, hematoxylin and eosin; pNPC, primary NPC; pNPCO, primary NPCO; rNPC, recurrent NPC; rNPCO, recurrent NPCO; IHC, immunohistochemistry; EBER, Epstein-Barr virus (EBV)-encoded small RNAs; ISH, in situ hybridization.