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. 2022 May;10(9):523. doi: 10.21037/atm-22-1756

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2022 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

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LncRNA-HFRL was upregulated in the ISO-induced mouse hearts. RNA-sequencing was performed to screen the differentially expressed lncRNAs. (A) Volcano plot showing the whole differentially expressed lncRNA genes. (B) Heatmap showing the top 50 most differentially expressed lncRNAs. (C) The top 10 most differentially expressed lncRNAs detected by qRT-PCR. (D) The expression of HFRL was increased treated by ISO. ^#, P<0.05; ^##, P<0.01. PBS, phosphate buffer saline; W, week; ISO, isoproterenol; DEG, differentially expressed gene; LncRNA, long non-coding ribonucleic acids; HFRL, heart failure-relative lncRNA; qRT-PCR, quantitative real-time polymerase chain reaction.