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. 2022 Aug 2;22:843. doi: 10.1186/s12885-022-09808-6

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Modulation of cellular viability and apoptosis in CP-modulated cells post-IR. Early and late apoptosis was evaluated by measure of annexin V positive cells and Ann V and IP positive cells, respectively, by flow cytometry in stable transfected U251-MG (A) and U87-MG GB (B) cell lines 24 h after a single exposure to 4 Gy- or 16 Gy-irradiation at 3% oxygen. Apoptosis is expressed as relative MFI of annexin V and PI ± SEM (n = 3). In same conditions but here 48 h after IR, MTS viability assay was performed in U251-MG (C) and U87-MG cells (D). MTS viability is expressed as DO ± SEM (n = 7). One-way ANOVA with multiple comparisons (each group was compared to their own normalized control) was performed between Control vs. irradiated cells (^*, p-value ≤ 0.05; ^**, p-value ≤ 0.01; ^***, p-value ≤ 0.001; ^****, p-value ≤ 0.0001)