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. 2022 Aug 3;42:25. doi: 10.1186/s41232-022-00209-7

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — TA improves cognitive function and ameliorates the Aβ pathology and neuronal damage in APP/PS1 mice. A The cognitive function of NC and APP/PS1 mice was evaluated by the MWM test. Bar charts indicate the escape latencies, the ratio of time spent in the target quadrant/total time, the number of mice crossing the platform, and average swimming speed (n ≥ 4). B The Western blotting detection of the protein expressions of Aβ, caspase-9, Bax, and Bcl-2 in the brain tissues of NC and APP/PS1 mice. Bar charts indicate the ratios of Aβ/β-actin, caspase-9 (p19)/Pro, Bax/Bcl-2. The full-length blots are presented in Additional file 1: Fig. S25. C Representative immunohistochemistry and immunofluorescence staining images showing the expressions of Aβ, NeuN, Bax, and TUNEL-positive neurons in the hippocampus of NC and APP/PS1 mice. Magnification: × 20; scale bar: 100 μm. Bar charts indicate the quantification of Aβ, NeuN, Bax, and TUNEL-positive neurons (n = 4). Error bars, S.D. *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001, n = 4. (One-way ANOVA with Tukey-corrected post hoc t-tests for multiple comparisons was applied for comparison between groups)