Table 5.

Univariate and multivariate analyses of predictors for long-term survival with Cox proportional hazards model

	Univariate		Multivariate
	HR(95%CI)	P value	HR(95%CI)	P value
Age	0.99(0.97,1.003)	0.986
Male	0.81(0.42,1.54)	0.517
BMI
Underweight	2.21(1.48,3.28)	< 0.001	1.89(1.22,2.93)	0.004*
Normal weight	Reference		Reference
Overweight-to-obesity	0.47(0.26,0.85)	0.012	0.75(0.39,1.43)	0.379
Cancer site
Oral cavity	Reference		Reference
Nasopharynx	1.31(0.77,2.23)	0.312	0.95(0.47,1.90)	0.881
Oropharynx	1.26(0.76,2.11)	0.373	1.14(0.63,2.07)	0.664
Hypopharynx	2.04(1.28,3.25)	0.003	1.43(0.85,2.40)	0.179
Larynx	0.98(0.46,2.09)	0.965	0.65(0.30,1.44)	0.291
Smoking history	1.09(0.69,1.73)	0.712
SBP < 90 (mmHg)	1.76(0.95,3.28)	0.074
Heart rate > 110 (beats/min)	2.00(1.38,2.88)	< 0.001	1.58(1.04,2.39)	0.032*
Hypertension	0.72(0.49,1.04)	0.082
Diabetes mellitus	0.77(0.50,1.19)	0.235
Surgical resection	0.60(0.42,0.86)	0.005	0.86(0.53,1.39)	0.856
Chemoradiation	3.15(1.83,5.42)	< 0.001	2.31(1.18,4.52)	0.015*
Neck dissection	0.88(0.62,1.26)	0.495
Flap reconstruction	0.96(0.66,1.39)	0.813
T stage	1.36(1.14,1.63)	0.001	1.16(0.94,1.42)	0.162
N stage	1.25(1.06,1.47)	0.008	1.11(0.90,1.37)	0.337
M stage	1.76(0.94,3.29)	0.075
Local recurrence	1.93(1.35,2.76)	< 0.001	1.74(1.14,2.67)	0.011*
Second primary cancer	1.37(0.93,2.00)	0.108
WBC > 11.0 (103/$\mu \mathrm{l}$)	1.48(1.03,2.12)	0.034	1.31(0.88,1.96)	0.190
Hb < 10.0 (g/dl)	1.90(1.35,2.73)	< 0.001	1.15(0.75,1.76)	0.530
PLT < 150 (103/$\mu \mathrm{l}$)	1.22(0.76,1.96)	0.401

HR Hazard ratio, 95% CI 95% Confidence interval

^*P value < 0.05