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letter
. 2022 May 31;38(4):491–553. doi: 10.1002/joa3.12717
Disease Diagnostic Prognostic Therapeutic
LVNC + +
Recommendation Consensus statement instruction Ref.
LVNC cardiomyopathy genetic testing may be useful for patients in whom a cardiologist has established a clinical diagnosis of LVNC based on examination of the patient’s clinical history, family history, and electrocardiographic/echocardiographic/MRI phenotype. graphic file with name JOA3-38-491-g008.jpg 387 , 394, 395, 396
Genetic testing may be useful for patients with a clinical diagnosis of LVNC cardiomyopathy associated with other cardiac or non‐cardiac syndromic features. graphic file with name JOA3-38-491-g008.jpg 397, 398, 399
Genetic testing should not be performed in isolated (incidental) LVNC with normal LV function, no associated syndromic features and no family history. graphic file with name JOA3-38-491-g010.jpg 387 , 394 400
Variant specific genetic testing may be considered for family members and appropriate relatives following the identification of the disease‐causative variant. graphic file with name JOA3-38-491-g008.jpg Expert opinion