Disease	Diagnostic	Prognostic	Therapeutic
Atrial fibrillation	–	+	–

Recommendation	Consensus statement instruction	Ref.
An analysis of SCN5A, KCNQ1, MYL4 and truncating TTN variants may be performed in all index patients in whom the diagnosis of familial (young = age < 60) AF, is established, based on examination of the patient’s clinical history, family history, and ECG characteristics.		234 , 235 , 236 , 237 , 238 , 239 , 240 , 241 , 242 , 243 Expert opinion
Variant‐specific genetic testing may be recommended for family members and appropriate relatives following the identification of the disease‐causative variant.		Expert opinion
Predictive genetic testing in related children may be considered in specific settings.		Expert opinion