Table II.
Current available evidence on using vitamin B for prophylaxis or management of diseases
| Review | Condition | Conclusion |
|---|---|---|
| Ang et al7, 2008 | Peripheral neuropathy | Evidence is insufficient to determine whether vitamin B is beneficial or harmful for treating peripheral neuropathy |
| Raval et al9, 2015 | Diabetic Kidney Disease (DKD) | No evidence to recommend the use of vitamin B therapy alone or in combination for delaying progression of DKD |
| Day10, 2013 | Wermicke-korsakoff syndrome (WKS) | Evidence is insufficient to determine the dose, frequency, route or duration of thiamine treatment for prophylaxis against WKS or its treatment due to alcohol abuse |
| Rodríguez11, 2001 | Alzheimer’s disease | Sample size in studies was <50 and the reported results were inadequate to suggest regarding the efficacy of thiamine in Alzheimer’s diseases. |
| Schandelmaier12, 2017 | Cardiovascular disease (CVD) | Evidence suggests that niacin does not reduce cardiovascular mortality from myocardial infarction or stroke but is associated with side effects |
| Malouf13, 2003 | Cognitive impairment | No evidence for short-term benefit from vitamin B6 supplementation in mood or cognitive functions could be found especially among elderly and people with dementia |
| Salam14, 2015 | Pregnancy and/or labour | Evidence is insufficient to determine the clinical benefits of vitamin B6 supplementation in pregnancy and/or labour. One clinical trial suggests protection against dental decay |
| De-Regil et al8, 2015 | Neural tube defects (NTDs) and other congenital anomalies (including cleft palate) | Folic acid, prevents NTDs, but does not have a clear effect on other birth defects |
| Lassi et al15, 2013 | Pregnancy outcomes (haematological and biochemical parameters during pregnancy) | No conclusive evidence to suggest that folic acid supplementation during pregnancy improves pregnancy outcomes like preterm birth and still birth/neonatal deaths |
| Shea et al16, 2013 | Rheumatoid arthritis and its treatment side effects | Supplementation with folic or folinic acid has a protective effect on patients with rheumatoid arthritis during treatment with methotrexate (MTX) |
| Malouf and Areosa Sastre17, 2003 | Cognitive impairment in demented and healthy elderly people | Insufficient evidence to determine the efficacy of vitamin B12 in improving the cognitive function among people with dementia and low serum B12 levels |