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. Author manuscript; available in PMC: 2022 Aug 3.
Published in final edited form as: Exp Gerontol. 2019 Oct 18;128:110739. doi: 10.1016/j.exger.2019.110739

Fig. 5.

Fig. 5.

Insulin-secreting function of isolated islets. (A) Stimulation index by GSIS (SI_GSIS) demonstrated age-associated decrease with > 41 week-old donors (2.34) having significantly lower SI compared to 10–20 week-old donors (5.81, p = 0.0472). n = 4 in 10–20 week-old and 21–40 week-old, and n = 3 in > 41 week-old donors. (B) Absolute insulin secretion analysis in low (basal) and high glucose conditions demonstrated significantly higher insulin secretion in the glucose-stimulated environment than under basal conditions in 10–20 week-old (p = 0.0335) and 21–40 week-old (p = 0.0207) donors but not in > 41 week-old donors (p = 0.3740).