Fig. 1. Cartoon representation of the Bcr-Abl SH2 domain, its mirror-image version and corresponding amino acid sequences from V138 to K241. The N- and C-terminal parts are in red and blue, respectively. Incorporation of the glycine–serine (GS) pseudoproline dipeptide (Fmoc-Gly-Ser(psiMe,Mepro)-OH) and the ligation site (A) are underlined and highlighted in bold black in the sequence. The sequence numbering is based on Abl isoform 1B. The structure of the Bcr-Abl SH2 domain was obtained from PDB (ID: 3K2M).
