Table 1.

Dosages and dose regimen of anti-inflammatory and immunosuppressive agents used in the 13-week mechanistic study

Group	Name	Concentration	Dose	Dose Volume	Route	Dosing Days
3	Prednisolone (10 mg as tablets)a	1 mg/mL	1 mg/kg/day	1 mL/kg	Oral (gavage)	Day −1 to 29, and then day 31, 33, 35, 37, 39, and 41
4	Rituximabb	10 mg/mL	20 mg/kg	2 mL/kg	Intravenous	Every 2 weeks (day −14, day −1, 14, 28, 42, 56, 70, and 84)
4	Everolimus (2.5 mg as tablets)a	0.5 mg/mL	0.5 mg/kg/day	1 mL/kg	Oral (gavage)	Daily, week −2 until end of the dosing phase (day 14)

^a As these are tablets, they were dissolved in normal drinking water and administered orally by gavage after a visual check for correct dissolution.

^b Diphenhydramine is an antihistamine, which has been administered intramuscularly as a premedication 30–60 min before rituximab administration at a concentration of 50 mg/mL, a dose of 4 mg/kg, and a volume of 0.08 mL/kg.