Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jul 13;33(13-14):695–707. doi: 10.1089/hum.2021.272

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Tiffany S. Nelson et al., 2022. Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License [CC-BY-NC] (http://creativecommons.org/licenses/by-nc/4.0/) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are cited.

PMC Copyright notice

Figure 4. — ERG responses in P23H^+/− mice 100 days after injection with AAV-ArrGG or AAV-ArrWT. Mice were injected intravitreally with AAV in one eye, with the contralateral eye receiving buffer. (A) Example of scotopic ERG waveforms elicited in response to increasing intensities of light flashes for a P23H^+/− mouse eye treated with ArrGG (green traces) compared with the contralateral eye injected with buffer (gray traces). (B) Summary quantitation of scotopic ERG response amplitudes at three flash intensities of a cohort of P23H^+/− mice treated with ArrGG (green bars, n = 4) or buffer (gray bars, n = 4). (C) Example scotopic ERG response to increasing intensities of light flashes for a P23H^+/− mouse eye treated with ArrWT (red traces) compared with the contralateral eye injected with buffer (gray traces). (D) Summary quantitation of scotopic ERG response amplitudes at three flash intensities of a cohort of P23H^+/− mice treated with ArrWT (red bars, n = 4) or buffer (gray bars, n = 4). Bars represent mean ± SEM, with statistical significance of parametric paired t-test comparisons indicated with an asterisk (ρ < 0.05); ns, not significant. Average scotopic ERG amplitudes in a nondegenerating retina are −50 μV (0.01 cd), −140 μV (1.0 cd), and −150 μV (3.0 cd) for the a-wave and 200 μV (0.01 cd), 300 μV (1.0 cd), and 350 μV (3.0 cd) for the b-wave. (E) Summary quantitation of photopic ERG response amplitudes at three flash intensities of a cohort of P23H^+/− mice treated with ArrGG in one eye (green bars, n = 4) and buffer in the contralateral eye (gray bars, n = 4), or treated with ArrWT in one eye (red bars, n = 4) and buffer in the contralateral eye (gray bars, n = 4). Bars indicate mean ± SEM, with statistical significance of parametric paired t-tests indicated with an asterisk (ρ < 0.05). Average photopic ERG amplitudes in a nondegenerating retina are 40 μV (2.0 cd), 60 μV (10.0 cd), and 80 μV (30.0 cd) for the b-wave. Color images are available online.