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. 2022 Jul 13;33(13-14):695–707. doi: 10.1089/hum.2021.272

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© Tiffany S. Nelson et al., 2022. Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License [CC-BY-NC] (http://creativecommons.org/licenses/by-nc/4.0/) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are cited.

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Figure 6. — Photoreceptors are preserved in P23H^+/− mice with reduced levels of Arr1 expression. (A) Summary quantitation of scotopic a-wave and b-wave ERG response amplitudes at three flash intensities of a cohort of P23H^+/− mice (red bars, n = 9; PN85 days) compared with P23H^+/− mice in the background of Arr1^+/− (green bars, n = 15; PN100 days). Bars represent mean ± SD, with statistical significance of parametric, unpaired t-test comparisons indicated with an asterisk (ρ < 0.05); ns, not significant. (B) ONL thickness was measured in P23H^+/− mice (red bars, n = 9) from OCT images collected at PN92 days and in P23H^+/− Arr1^+/− mice at PN107 days (green bars, n = 16); ONL measurements are shown at 1,200 μm from the optic nerve head in the temporal retina. Statistical comparison at each time point showed significantly thicker ONL in eyes of P23H^+/− mice in the Arr1^+/− background compared with eyes from P23H^+/− mice in the Arr1^+/+ background (bars represent mean ± SD, with statistical significance of parametric, unpaired t-test comparisons indicated with an asterisk (ρ < 0.05). Color images are available online.