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. 2022 Jun 11;94(10):4599–4610. doi: 10.1002/jmv.27907

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© 2022 Wiley Periodicals LLC.

This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

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Schematic diagram shows the contribution of bovine‐derived biotherapeutics to human health. Humans can be supplied with hyperimmunized milk from transchromosomic (Tc) bovines, which can be utilized to make dairy products with protective antibodies. Also, Tc bovine vaccination triggers the adaptive immune response in cattle, allowing Tc bovine B cells to release human polyclonal antibodies that target a wide range of epitopes, reducing the risk of viral infections gaining mutational resistance.