Table 4.
Allelic and genotypic distribution of the studied polymorphisms, number (percentage%)
| SNP | COVID‐19 N (%) | Control N (%) | Genetic model | OR (95% CI) | p value |
|---|---|---|---|---|---|
| rs361525 G>A ( TNFA ) | |||||
| GG | 90 (28.4) | 101 (31.9) | 1 [Reference] | ||
| GA | 141 (44.5) | 170 (53.6) | GA versus GG | 0.93 (0.65−1.34) | .697 |
| AA | 86 (27.1) | 46 (14.5) | AA versus GG | 2.10 (1.33−3.31) | <.001 * |
| HWE | ‐ | 0.059 | Dominant | 1.18 (0.84−1.66) | .341 |
| Recessive | 2.19 (1.47−3.27) | <.0001* | |||
| Over dominant | 0.69 (0.51−0.95) | <.021 * | |||
| G | 321 (50.6) | 372 (58.7) | Allelic | 1 [Reference] | |
| A | 313 (49.4) | 262 (41.3) | Allelic | 1.38 (1.11−1.73) | <.004 * |
| rs419598 T>C (IL1RN) | |||||
| TT | 145 (45.7) | 179 (56.5) | 1 [Reference] | ||
| TC | 134 (42.3) | 113 (35.6) | TC versus TT | 1.46 (1.05−2.04) | .024 * |
| CC | 38 (12.0) | 25 (7.9) | CC versus TT | 1.88 (1.08−3.25) | .024 * |
| HWE | ‐ | 0.234 | Dominant | 1.54 (1.12−2.10) | <.007 * |
| Recessive | 1.59 (0.94−2.70) | .084 | |||
| Over dominant | 1.32 (0.96−1.82) | .087 | |||
| T | 424 (66.9) | 471 (74.3) | Allelic | 1 [Reference]− | |
| C | 210 (33.1) | 163 (25.7) | Allelic | 1.43 (1.12−1.82) | <.004 * |
| rs2228145 A>C (IL6R) | |||||
| CC | 96 (30.3) | 107 (33.7) | 1 [Reference]‐ | ||
| AC | 155 (48.9) | 168 (53.0) | AC versus CC | 1.03 (0.72−1.46) | .876 |
| AA | 66 (20.8) | 42 (13.2) | AA versus CC | 1.75 (1.09−2.82) | .020 * |
| HWE | ‐ | 0.058 | Dominant | 1.17 (0.84−1.64) | .349 |
| Recessive | 1.72 (1.13−2.63) | .011 * | |||
| Over dominant | 0.85 (0.62−1.16) | .302 | |||
| C | 347 (54.7) | 382 (60.3) | Allelic | 1 [Reference] | |
| A | 287 (45.3) | 252 (39.7) | Allelic | 1.25 (1.00−1.57) | .047 * |
| rs2069827 G>T (IL6) | |||||
| GG | 143 (45.1) | 116 (36.6) | 1 [Reference]‐ | ||
| GT | 136 (42.9) | 146 (46.0) | GT versus GG | 0.76 (0.54−1.06) | .104 |
| TT | 38 (12.0) | 55 (17.4) | TT versus GG | 0.56 (0.35−0.91) | .018 * |
| HWE | ‐ | 0.439 | Dominant | 0.70 (0.51−0.97) | .029 * |
| Recessive | 0.65 (0.41−1.01) | .056 | |||
| Over dominant | 0.88 (0.64−1.20) | .424 | |||
| G | 422 (66.6) | 378 (59.6) | Allelic | 1 [Reference] | |
| T | 212 (33.4) | 256 (40.4) | Allelic | 0.74 (0.59−0.93) | .010 * |
Abbreviations: CI, confidence interval; COVID‐19, coronavirus 2019; HWE, Hardy−Weinberg equilibrium; OR, odds ratio; SNP, single‐nucleotide polymorphism.
*
p < .05 (bolded p values) was considered statistically significant.