Table 5.
Demographic, radiologic (CT‐scan) and laboratory characters of the studied cases according to genotype distribution, parameters described as mean ± SD, number (percentage%)
| Parameter evaluated | Case genotypes (TNFA) rs361525 G>A | Test of Sig | Within‐group significant | Case genotypes (IL1RN) rs419598 T>C | Test of Sig | Within‐group significant | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GG | GA | AA | TT | TC | CC | |||||||
| N = 90 | N = 141 | N = 86 | N = 145 | N = 134 | N = 38 | |||||||
| Age (year) | 55.81 ± 13.67 | 53.26 ± 14.13 | 57.87 ± 13.91 | F: 3.03 | P 1: 0.529 | 54.64 ± 14.49 | 56.84 ± 12.51 | 51.87 ± 16.7 | F: 2.11 | P 1: 0.574 | ||
| p = .05 | P 2: 0.049 | p: .123 | P 2: 0.162 | |||||||||
| P 3: 0.983 | P 3: 0.832 | |||||||||||
| Gender (female/male) | 32/58 | 56/85 | 35/51 | χ 2: 0.579 | P 1: 0.676 | 55/90 | 50/84 | 18/20 | χ 2: 1.35 | P 1: 0.809 | ||
| p: .749 | P 2: 0.576 | p: .510 | P 2: 0.833 | |||||||||
| P 3: 0.314 | P 3: 0.945 | |||||||||||
| WBC count (×109/L) | 9.46 ± 5.2 | 9.27 ± 4.16 | 9.21 ± 4.7 | F: 0.07 | P 1: 1.000 | 9.42 ± 5.05 | 9.15 ± .4.2 | 9.43 ± 4.28 | F: 0.136 | P 1: 1.000 | ||
| p: .931 | P 2: 1.000 | p: .873 | P 2: 1.000 | |||||||||
| P 3: 1.000 | P 3: 1.000 | |||||||||||
| Plt count (× 109/L) | 244.32 ± 102.09 | 248.01 ± 98.72 | 247.88 ± 91.14 | F: 0.045 | P 1: 1.000 | 246.55 ± 100.4 | 245.69 ± 95.17 | 252.76 ± 96.03 | F: 0.080 | P 1: 1.000 | ||
| p: .956 | P 2: 1.000 | p: .923 | P 2: 1.000 | |||||||||
| P 3: 1.000 | P 3: 1.000 | |||||||||||
| Lymph count (×109/L) | 1.06 ± 0.57 | 1.02 ± 0.57 | 0.91 ± 0.45 | F: 1.54 | P 1: 1.000 | 1.02 ± 0.53 | 0.94 ± 0.56 | 1.09 ± 0.53 | F: 1.49 | P 1: 0.650 | ||
| p: .214 | P 2: 0.700 | p: .227 | P 2: 0.365 | |||||||||
| P 3: 0.248 | P 3: 1.000 | |||||||||||
| Neut count (×109/L) | 7.86 ± 4.83 | 7.65 ± 4.11 | 7.69 ± 4.49 | F: 0.08 | P 1: 1.000 | 7.74 ± 4.74 | 7.66 ± 4.16 | 7.87 ± 4.03 | F: 0.035 | P 1: 1.000 | ||
| p: .935 | P 2: 1.000 | p: .965 | P 2: 1.000 | |||||||||
| P 3: 1.000 | P 3: 1.000 | |||||||||||
| CRP (mg/L) | 14.62 ± 4.97 | 15.49 ± 4.43 | 15.33 ± 4.02 | F: 0.05 | P 1: 0.471 | 14.99 ± 4.59 | 15.52 ± 4.36 | 14.84 ± 4.91 | F: 0.607 | P 1: 0.993 | ||
| p: .990 | P 2: 1.000 | p: .545 | P 2: 1.000 | |||||||||
| P 3: 0.912 | P 3: 1.000 | |||||||||||
| LDH (IU/L) | 664.37 ± 257.69 | 750.5 ± 366.91 | 691.03 ± 243.37 | F: 2.37 | P 1: 0.117 | 713.52 ± 280.44 | 713.78 ± 343.67 | 682.55 ± 292.95 | F: 0.168 | P 1: 1.000 | ||
| p: .095 | P 2: 0.478 | p: .845 | P 2: 1.000 | |||||||||
| P 3: 1.000 | P 3: 1.000 | |||||||||||
| ESR (mm/h) | 48.38 ± 25.81 | 50.29 ± 21.61 | 50.02 ± 23.26 | F: 0.198 | P 1: 1.000 | 51.54 ± 21.76 | 47.21 ± 24.94 | 51.24 ± 22.32 | F: 1.311 | P 1: 0.361 | ||
| p: .820 | P 2: 1.000 | p: 0.271 | P 2: 1.000 | |||||||||
| P 3: 1.000 | P 3: 1.000 | |||||||||||
| NLR (index) | 09.53 ± 6.77 | 10.15 ± 8.11 | 10.06 ± 8.36 | F: 0.184 | P 1: 1.000 | 09.72 ± 8.23 | 10.62 ± 7.71 | 8.48 ± 6.22 | F: 1.222 | P 1: 1.000 | ||
| p: 0.832 | P 2: 1.000 | p: 0.296 | P 2: 0.414 | |||||||||
| P 3: 1.000 | P 3: 1.000 | |||||||||||
| PLR (index) | 291.64 ± 183.71 | 325.4 ± 242.1 | 317.80 ± 211.64 | F: 0.675 | P 1: 0.760 | 299.84 ± 224.71 | 339.57 ± 225.96 | 275.9 ± 151.82 | F: 1.809 | P 1: 0.388 | ||
| 8 | p: .510 | P 2: 1.000 | p: .166 | P 2: 0.339 | ||||||||
| P 3: 1.000 | P 3: 1.000 | |||||||||||
| SII (index) | 2494.3 ± 2235.6 | 2548.2 ± 2262.1 | 2519.1 ± 2268.2 | F: 0.016 | P 1: 1.000 | 2477.2 ± 2359.26 | 2710.21 ± 2255.2 | 2054.5 ± 1703.72 | F: 1.321 | P 1: 1.000 | ||
| p: .984 | P 2: 1.000 | p: .268 | P 2: 0.340 | |||||||||
| P 3: 1.000 | P 3: 0.908 | |||||||||||
| SpO2 (%) | 85.35 ± 8.32 | 84.78 ± 8.73 | 86.25 ± 5.66 | F: 0.933 | P 1: 1.000 | 86.16 ± 7.34 | 84.24 ± 8.93 | 86.10 ± 5.29 | F: 2.294 | P 1: 0.388 | ||
| p: .394 | P 2: 0.519 | p: .103 | P 2: 0.339 | |||||||||
| P 3: 1.000 | P 3: 1.000 | |||||||||||
| No lesion in CT | 2 (2.2) | 2 (1.4) | 4 (4.7) | χ 2: 0.738 | P 1: 0.527 | 4 (2.8) | 4 (3.0) | 0 (0) | χ 2: 1.63 | P 1: 0.441 | ||
| P 2: 0.702 | p: .442 | P 2: ‐‐ | ||||||||||
| Lesion in CT | 88 (97.8) | 139 (98.6) | 82 (95.3) | p: .691 | P 3: 0.383 | 141 (97.2) | 130 (97.0) | 38 (100.0) | P 3: ‐‐ | |||
| Parameter evaluated | Case genotypes ( IL6R ) rs2228145 A > C | Test of Sig | Within‐group significant | Case genotypes ( IL6 ) rs2069827 G > T | Test of Sig | Within‐group significant | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AA | AC | CC | GG | GT | TT | |||||||
| N = 66 | N = 155 | N = 96 | N = 143 | N = 136 | N = 38 | |||||||
| Age (year) | 54.33 ± 11.93 | 56.63 ± 14.39 | 53.61 ± 14.68 | F: 1.54 | P 1: 0.799 | 55.44 ± 14.94 | 54.92 ± 13.06 | 55.61 ± 14.20 | F: 0.063 | P 1: 1.000 | ||
| p: .215 | P 2: 0.297 | p: .939 | P 2: 1.000 | |||||||||
| P 3: 1.000 | P 3: 1.000 | |||||||||||
| Gender (female/male) | 22/44 | 63/92 | 38/58 | χ 2: 1.08 | P 1: 0.462 | 55/88 | 54/82 | 14/24 | χ 2: 0.12 | P 1: 0.928 | ||
| p: .583 | P 2: 0.209 | p: .944 | P 2: 0.675 | |||||||||
| P 3: 0.616 | P 3: 0.715 | |||||||||||
| WBC count (×109/L) | 9.92 ± 5.73 | 8.99 ± 3.87 | 9.38 ± 4.87 | F: 0.962 | P 1: 0.512 | 9.58 ± 4.99 | 8.94 ± 3.84 | 9.57 ± 5.64 | F: 0.744 | P 1: 0.741 | ||
| p: .383 | P 2: 1.000 | p: .476 | P 2: 1.000 | |||||||||
| P 3: 1.000 | P 3: 1.000 | |||||||||||
| Plt count (×109/L) | 249.65 ± 113.1 | 241.25 ± 87.71 | 254.24 ± 101.3 | F: 0.558 | P 1: 1.000 | 244.17 ± 97.49 | 250.60 ± 99.06 | 244.21 ± 93.19 | F: 0.168 | P 1: 1.000 | ||
| p: .573 | P 2: 0.918 | p: .884 | P 2: 1.000 | |||||||||
| P 3: 1.000 | P 3: 1.000 | |||||||||||
| Lymph count (×109/L) | 0.99 ± 0.49 | 0.91 ± 0.48 | 1.13 ± 0.64 | F: 4.854 | P 1: 1.000 | 1.02 ± 0.53 | 0.97 ± 0.56 | 0.97 ± 0.55 | F: 0.40 | P 1: 1.000 | ||
| p : <.008 * | P 2 : < 0.006 * | p: .846 | P 2: 1.000 | |||||||||
| P 3: 0.278 | P 3: 1.000 | |||||||||||
| Neut count | 8.22 ± 5.1 | 7.53 ± 3.92 | 7.7 ± 4.67 | F: 0.585 | P 1: 0.842 | 7.99 ± 4.64 | 7.41 ± 3.8 | 7.87 ± 5.48 | F: 0.64 | P 1: 0.801 | ||
| (×109/L) | p: .558 | P 2: 1.000 | p: .528 | P 2: 1.000 | ||||||||
| P 3: 1.000 | P 3: 1.000 | |||||||||||
| CRP (mg/L) | 15.18 ± 4.45 | 15.52 ± 4.31 | 14.69 ± 4.91 | F: 1.007 | P 1: 1.000 | 14.73 ± 4.71 | 15.81 ± 4.14 | 14.79 ± 5.02 | F: 2.17 | P 1: 0.139 | ||
| p: .366 | P 2: .471 | p: .115 | P 2: 1.000 | |||||||||
| P 3: 1.000 | P 3: 1.000 | |||||||||||
| LDH (IU/L) | 717.17 ± 251.58 | 706.58 ± 323. | 710.31 ± 324.14 | F: 0.027 | P 1: 1.000 | 713.31 ± 318.86 | 703.16 ± 296.42 | 721.29 ± 325.89 | F: 0.066 | P 1: 1.000 | ||
| 8 | p: .973 | P 2: 1.000 | p: .936 | P 2: 1.000 | ||||||||
| P 3: 1.000 | P 3: 1.000 | |||||||||||
| ESR (mm/h) | 51.26 ± 22.74 | 48.01 ± 23.96 | 51.28 ± 22.45 | F: 0.780 | P 1: 1.000 | 50.10 ± 23.60 | 48.89 ± 23.32 | 50.89 ± 22.13 | F: 0.153 | P 1: 1.000 | ||
| p: .459 | P 2: 0.838 | p: .858 | P 2: 1.000 | |||||||||
| P 3: 1.000 | P 3: 1.000 | |||||||||||
| NLR (index) | 10.22 ± 8.8 | 10.22 ± 7.85 | 9.32 ± 7.00 | F: 0.444 | P 1: 1.000 | 10.41 ± 9.04 | 9.53 ± 6.74 | 09.72 ± 06.26 | F: 0.461 | P 1: 1.000 | ||
| p: .642 | P 2: 1.000 | p: .631 | P 2: 1.000 | |||||||||
| P 3: 1.000 | P 3: 1.000 | |||||||||||
| PLR (index) | 292.97 ± 178.52 | 328.69 ± 235. | 303.97 ± 215.79 | F: 0.456 | P 1: 0.802 | 299.27 ± 217.68 | 330.98 ± 233.94 | 306.69 ± 155.69 | F: 0.755 | P 1: 0.681 | ||
| 2 | p: .471 | P 2: 1.000 | p: .471 | P 2: 1.000 | ||||||||
| P 3: 1.000 | P 3: 1.000 | |||||||||||
| SII (index) | 2622.3 ± 2581.2 | 2507.9 ± 2198.2 | 2485.7 ± 2104.2 | F: 0.080 | P 1: 1.000 | 2553.8 ± 2372.2 | 2464.7 ± 2104.3 | 2632.6 ± 2329.3 | F: 0.104 | P 1: 1.000 | ||
| p: .923 | P 2: 1.000 | p: .902 | P 2: 1.000 | |||||||||
| P 3: 1.000 | P 3: 1.000 | |||||||||||
| SpO2 (%) | 84.61 ± 9.15 | 85.53 ± 7.56 | 85.56 ± 7.53 | F:0.363 | P 1: 1.000 | 84.71 ± 8.57 | 86.22 ± 7.04 | 84.57 ± 8.1 | F: 1.49 | P 1: 0.334 | ||
| p: .696 | P 2: 1.000 | p: .230 | P 2: 0.772 | |||||||||
| P 3: 1.000 | P 3: 1.000 | |||||||||||
| No lesion in CT | 3 (4.5) | 4 (2.6) | 1 (1.0) | χ 2: 6.59 | P 1: 0.875 | 5 (3.5) | 2 (1.5) | 1 (2.6) | χ 2: 3.40 | P 1: 0.877 | ||
| p: .360 | P 2: 0.456 | p: .757 | P 2: 0.568 | |||||||||
| Lesion in CT | 63 (95.5) | 151 (97.4) | 95 (99.0) | P 3: 0.324 | 138 (96.5) | 134 (98.5) | 37 (97.4) | P 3: 0.996 | ||||
Abbreviations: CRP, C‐reactive protein; CT, computed tomography; ESR, erythrocyte sedimentation rate; LDH, lactate dehydrogenase; Lymph, lymphocyte; Neut, neutrophil; NLR: neutrophil‐to‐lymphocyte ratio; PLR, platelet‐to‐lymphocyte ratio; Plt: platelet; SII, systemic immune‐inflammation index; SpO2, blood oxygen saturation levels, WBC, white blood cell.
*
p < .0125 (bolded p values) was considered statistically significant. In TNFA, P 1: difference between GG & GA, P 2: difference between AA & GA, P 3: difference between GG & AA. In IL1RN, P 1: difference between TT & TC, P 2: difference between CC & TC, P 3: difference between CC & TT. In IL6R, P 1: difference between AA & AC, P 2: difference between CC & AC, P 3: difference between AA & CC. In IL6, P 1: difference between GG & GT, P 2: difference between TT & GT, P 3: difference between GG & TT.