Table 6.
Disease severity and prognosis in different genotypes of the studied cases, parameters described as mean ± SD, number (percentage%)
| Parameter evaluated | Case genotypes (TNFA) rs361525 G>A | Test of significance | Within‐group significant | Case genotypes (IL1RN) rs419598 T>C | Test of significance | Within‐group significant | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| GG | GA | AA | TT | TC | CC | |||||
| N = 90 | N = 141 | N = 86 | N = 145 | N = 134 | N = 38 | |||||
| Severity of disease | ||||||||||
| Severe | 49 (54.4) | 95 (67.4) | 59 (68.6) | χ 2: 5.05 | P 1: 0.033 * | 86 (59.3) | 92 (68.7) | 25 (65.8) | χ 2: 2.69 | P 1: 0.067 |
| Nonsevere | 41 (45.6) | 46 (32.6) | 27 (31.4) | p: .08 | P 2: 0.483 | 59 (40.7) | 42 (31.3) | 13 (34.2) | p: .259 | P 2: 0.440 |
| P 3: 0.038 * | P 3: 0.296 | |||||||||
| Survival | ||||||||||
| Survived | 82 (91.1) | 131 (92.9) | 78 (90.7) | χ 2: 0.42 | P 1: 0.398 | 132 (91.0) | 123 (91.8) | 36 (94.7) | χ 2: 0.548 | P 1: 0.496 |
| Deceased | 8 (8.9) | 10 (7.1) | 8 (9.3) | p: .808 | P 2: 0.360 | 13 (9.0) | 11 (8.2) | 2 (5.3) | p: .760 | P 2: 0.420 |
| P 3: 0.565 | P 3: 0.361 | |||||||||
| Parameter evaluated | Case genotypes ( IL6R ) rs2228145 A>C | Test of significance | Within‐group significant | Case genotypes ( IL6 ) rs2069827 G>T | Test of significance | Within‐group significant | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| AA | AC | CC | GG | GT | TT | |||||
| N = 66 | N = 155 | N = 96 | N = 143 | N = 136 | N = 38 | |||||
| Severity of disease | ||||||||||
| Severe | 40 (60.6) | 102 (65.8) | 61 (63.5) | χ 2: 0.558 | P 1: .0278 | 95 (66.4) | 83 (61.0) | 25 (65.8) | χ 2: 0.94 | p 1: 0.208 |
| P 2: 0.408 | p 2: 0.368 | |||||||||
| Nonsevere | 26 (39.4) | 53 (34.2) | 35 (36.5) | p: .756 | P 3: 0.414 | 48 (33.6) | 53 (39.0) | 13 (34.2) | p: .625 | p 3: 0.542 |
| Survival | ||||||||||
| Survived | 63 (95.5) | 139 (89.7) | 89 (92.7) | χ 2: 2.20 | P 1: 0.125 | 128 (89.5) | 128 (94.1) | 35 (92.1) | χ 2: 1.97 | P 1: 0.118 |
| P 2: 0.283 | P 2: 0.445 | |||||||||
| Deceased | 3 (4.5) | 16 (10.3) | 7 (7.3) | p: .332 | P 3: 0.359 | 15 (10.5) | 8 (5.9) | 3 (7.9) | p: .373 | P 3: 0.452 |
*
p < .05 (bolded p values) was considered statistically significant. In TNFA, P 1: difference between GG & GA, P 2: difference between AA & GA, P 3: difference between GG & AA. In IL1RN, P 1: difference between TT & TC, P 2: difference between CC & TC, P 3: difference between CC & TT. In IL6R, P 1: difference between AA & AC, P 2: difference between CC & AC, P 3: difference between AA & CC. In IL6, P 1: difference between GG & GT, P 2: difference between TT & GT, P 3: difference between GG & TT.