Table 7.

Interaction analysis of the studied SNPs on COVID‐19 risk, number (percentage%)

rs361525 G>A	rs419598 T>C	rs2228145 A>C	rs2069827 G>T	COVID‐19	Control
(TNFA)	(IL1RN)	(IL6R)	(IL6)	N (%)	N (%)	OR (95% CI)	p value
AA	CT	CC	GG	12 (3.8)	32 (10.1)	1 [Reference]
GG	TT	CC	GG	5 (1.6)	11 (3.5)	1.21 (0.35−4.22)	.762
AA	CT	CA	GT	5 (1.7)	2 (0.7)	6.67 (1.14−39.10)	.021 *
AA	CT	CC	GT	6 (2.1)	2 (0.7)	8.00 (1.41−45.23)	<.009 *
AA	TT	CA	GG	2 (0.6)	7 (2.2)	0.76 (0.14−4.19)	.754
AA	TT	CA	GT	3 (1.0)	4 (14)	2.00 (0.39−10.28)	.401
AA	TT	CC	GG	3 (0.9)	5 (1.6)	1.60 (0.33−7.75)	.557
AA	TT	CC	GT	3 (0.9)	4 (1.3)	2.00 (0.39−10.28)	.401
AG	CT	AA	GG	3 (0.9)	7 (2.2)	1.14 (0.25−5.15)	.862
AG	CT	CC	GG	11 (3.5)	8 (2.5)	3.67 (1.19−11.31)	.021 *
AG	TT	AA	GG	7 (2.2)	10 (3.2)	1.87 (0.58‐6.02)	.293
AG	TT	CA	GG	26 (8.2)	16 (5.0)	4.33 (1.74−10.76)	<.001 *
AG	TT	CC	GG	16 (5.0)	7 (2.2)	6.09 (2.01−18.47)	<.001 *
AG	TT	CC	GT	8 (2.50	12 (3.8)	1.78 (0.58−5.41)	.309
GG	CT	AA	GG	6 (1.9)	3 (0.9)	5.33 (1.15−24.79)	.023 *
GG	CT	AA	GT	2 (0.6)	4 (1.3)	1.33 (0.22−8.25)	.756
GG	CT	CA	GG	4 (1.3)	3 (0.9)	3.56 (0.69−18.28)	.114
GG	CT	CA	GT	3 (0.9)	6 (1.9)	1.33 (0.29−6.20)	.713
GG	CT	CC	GG	5 (1.6)	2 (0.6)	6.67 (1.14−39.10)	.021 *
GG	CT	CC	GT	5 (1.6)	7 (2.2)	1.90 (0.51−7.17)	.336
GG	TT	AA	GG	3 (0.9)	7 (2.2)	1.14 (0.25−5.15)	.862
GG	TT	CA	GG	8 (2.5)	11 (3.5)	1.94 (0.63−5.98)	.246
GG	TT	CA	GT	20 (6.3)	10 (3.2)	5.33 (1.95−14.62)	<.001 *
GG	TT	CC	GT	9 (2.8)	2 (0.6)	12.00 (2.26−63.72)	<.001 *
GG	TT	CC	TT	6 (1.9)	4 (1.3)	4.00 (0.96−16.69)	.048 *

Note: Genotype frequencies less than 0.01 were excluded.

Abbreviations: CI, confidence interval; COVID‐19, coronavirus 2019; OR, odds ratio.

^* p < .05 (bolded p values) was considered statistically significant.