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. 2022 Jun 3;94(9):4533–4538. doi: 10.1002/jmv.27882

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© 2022 Wiley Periodicals LLC.

This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

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Neutralization antibody titer and overall mean binding and neutralizing antibody titer induced by the third‐dose booster vaccination with each receptor‐binding domain (RBD) variant against the authentic wild‐type Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and its variants. Neutralization antibody titer of the sera after the third‐dose booster vaccination with wild type, Alpha, Beta, Gamma, Delta, Kappa, or Omicron against (A) the wild type, (B) Alpha, (C) Beta, (D) Gamma, (E) Delta, and (F) Omicron SARS‐CoV‐2 virus strain. (G) Overall mean binding and (H) neutralizing antibodies titer induced by booster vaccination with each RBD variant against various SARS‐CoV‐2 virus strains. The ratio of antibody titer against each variant to antibody titer against wild‐type strains was shown, the black bars indicate mean values. Statistical analysis was performed using the paired t‐test.