Table 3.
Adverse reaction or obstetric and gynecological symptoms of pregnant women after vaccination
| First vaccination | Second vaccination | p‐Value a | Effect size b | |||
|---|---|---|---|---|---|---|
| n | % | n | % | |||
| Adverse reactions | (n = 5032) | (n = 4587) | ||||
| Pain at the inoculation site | 4873 | 96.84 | 4248 | 92.61 | <0.001 | 0.095 |
| Swelling at the inoculation site | 1511 | 30.03 | 1470 | 32.05 | 0.032 | 0.022 |
| Fever | 608 | 12.08 | 2554 | 55.68 | <0.001 | 0.464 |
| Fatigue/malaise | 1504 | 29.89 | 3003 | 65.47 | <0.001 | 0.356 |
| Headache | 711 | 14.13 | 1756 | 38.28 | <0.001 | 0.276 |
| Uncomfortable/vomiting | 191 | 3.80 | 506 | 11.03 | <0.001 | 0.139 |
| Diarrhea | 103 | 2.05 | 137 | 2.99 | 0.003 | 0.030 |
| Abdominal pain | 54 | 1.07 | 114 | 2.49 | <0.001 | 0.054 |
| Arthralgia | 220 | 4.37 | 1022 | 22.28 | <0.001 | 0.267 |
| Rash | 51 | 1.01 | 47 | 1.02 | 0.957 | 0.001 |
| Sore throat | 30 | 0.60 | 53 | 1.16 | 0.003 | 0.030 |
| Anaphylactic reaction | 1 | 0.02 | 4 | 0.09 | 0.199 | 0.015 |
| Others | 159 | 3.16 | 240 | 5.23 | <0.001 | 0.052 |
| Obstetric and gynecological symptoms | (n = 5393) | (n = 4834) | ||||
| Uterine tension or contraction | 89 | 1.65 | 144 | 2.98 | <0.001 | 0.044 |
| Bleeding | 46 | 0.85 | 38 | 0.79 | 0.708 | 0.004 |
| Uterin pain | 23 | 0.43 | 51 | 1.06 | <0.001 | 0.037 |
| Decreased fetal movement | 23 | 0.43 | 25 | 0.52 | 0.503 | 0.007 |
| Swelling | 17 | 0.32 | 19 | 0.39 | 0.507 | 0.007 |
| Increased blood pressure | 5 | 0.09 | 7 | 0.14 | 0.442 | 0.008 |
| Amniorrhexis | 1 | 0.02 | 2 | 0.04 | 0.606 | 0.007 |
| Others | 98 | 1.82 | 108 | 2.23 | 0.134 | 0.015 |
a
Using the chi‐squared test or Fisher's exact test.
b
Effect size was calculated by Cramer's V (≥0.1: small, ≥0.3: medium, ≥0.5: large) for the chi‐square test.