Comparison 2. Primary outcome: number of non‐invasive and invasive tests ‐ all time points.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
2.1 Number of invasive tests	4		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
2.1.1 at baseline	3	59222	Risk Ratio (M‐H, Random, 95% CI)	2.90 [2.25, 3.75]
2.1.2 at follow‐up	3	60003	Risk Ratio (M‐H, Random, 95% CI)	2.60 [2.41, 2.80]
2.2 Non‐invasive tests	3		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
2.2.1 at baseline	3	59222	Risk Ratio (M‐H, Random, 95% CI)	3.28 [2.40, 4.48]
2.2.2 at follow‐up	2	55905	Risk Ratio (M‐H, Random, 95% CI)	3.56 [1.81, 7.01]
2.3 Number of invasive test for false positive	4	63323	Risk Ratio (M‐H, Random, 95% CI)	3.84 [3.18, 4.64]
2.3.1 at baseline	1	3318	Risk Ratio (M‐H, Random, 95% CI)	3.09 [1.57, 6.07]
2.3.2 at follow‐up	3	60005	Risk Ratio (M‐H, Random, 95% CI)	3.91 [3.21, 4.76]
2.4 Death postsurgery	2	409	Risk Ratio (M‐H, Random, 95% CI)	0.68 [0.24, 1.94]