Comparison 3. Secondary outcome: all‐cause mortality.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
3.1 All‐cause mortality ‐ planned time points (latest time points)	8	91107	Risk Ratio (M‐H, Random, 95% CI)	0.95 [0.91, 0.99]
3.2 All‐cause mortality ‐ all time points (planned and unplanned)	9		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
3.2.1 5 to 6 years	3	11474	Risk Ratio (M‐H, Random, 95% CI)	1.14 [0.88, 1.47]
3.2.2 > 6 to 8 years	2	57422	Risk Ratio (M‐H, Random, 95% CI)	0.94 [0.89, 0.99]
3.2.3 > 8 to 10 years	6	33685	Risk Ratio (M‐H, Random, 95% CI)	0.97 [0.91, 1.03]
3.2.4 > 10 years	2	56658	Risk Ratio (M‐H, Random, 95% CI)	0.91 [0.76, 1.09]
3.3 All‐cause mortality ‐ planned time points	3		Hazard Ratio (IV, Random, 95% CI)	Subtotals only
3.3.1 any time points	3		Hazard Ratio (IV, Random, 95% CI)	0.98 [0.87, 1.12]
3.4 All‐cause mortality by sex ‐ planned time points	3		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
3.4.1 females	2	24514	Risk Ratio (M‐H, Random, 95% CI)	0.89 [0.76, 1.03]
3.4.2 males	3	49162	Risk Ratio (M‐H, Random, 95% CI)	0.93 [0.80, 1.07]
3.5 Cardiovascular mortality ‐ planned and unplanned	2		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
3.5.1 8 to 10 years	2		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
3.5.2 > 10 years ‐ unplanned	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected