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. 2022 Aug 3;2022(8):CD013829. doi: 10.1002/14651858.CD013829.pub2

Comparison 4. Secondary outcome: lung cancer incidence.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
4.1 Lung cancer incidence ‐ by different time points 10   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
4.1.1 at baseline 6 79900 Risk Ratio (M‐H, Random, 95% CI) 4.98 [2.01, 12.35]
4.1.2 at year 1 3 73345 Risk Ratio (M‐H, Random, 95% CI) 2.12 [1.35, 3.31]
4.1.3 at year 2 2 57556 Risk Ratio (M‐H, Random, 95% CI) 1.88 [1.51, 2.32]
4.1.4 at year 3 1 4104 Risk Ratio (M‐H, Random, 95% CI) 1.71 [0.68, 4.35]
4.1.5 at year 4 1 4104 Risk Ratio (M‐H, Random, 95% CI) 2.67 [1.05, 6.80]
4.1.6 5 to 7 years 2 57506 Risk Ratio (M‐H, Random, 95% CI) 1.13 [1.04, 1.23]
4.1.7 > 7 years 8 88528 Risk Ratio (M‐H, Random, 95% CI) 1.17 [1.02, 1.33]
4.2 Lung cancer incidence ‐ by control group at ≥ 10 years 6 82110 Risk Ratio (M‐H, Random, 95% CI) 1.15 [0.99, 1.34]
4.2.1 usual care 5 28656 Risk Ratio (M‐H, Random, 95% CI) 1.21 [0.99, 1.48]
4.2.2 CXR 1 53454 Risk Ratio (M‐H, Random, 95% CI) 1.01 [0.95, 1.08]
4.3 Overdiagnosis at ≥ 10 years 6   Risk Difference (IV, Random, 95% CI) Subtotals only
4.3.1 usual care 5 28656 Risk Difference (IV, Random, 95% CI) 0.18 [‐0.00, 0.36]
4.3.2 CXR 1 53454 Risk Difference (IV, Random, 95% CI) 0.01 [‐0.05, 0.07]