| 7.1 Anxiety ‐ at 10 months to 5 years (change over time and endpoints) |
3 |
8153 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.43 [‐0.59, ‐0.27] |
| 7.2 Quality of life measures at different time points |
3 |
|
Mean Difference (IV, Random, 95% CI) |
Subtotals only |
| 7.2.1 Physical component summary of short‐form 12 (PCS) at baseline |
1 |
1288 |
Mean Difference (IV, Random, 95% CI) |
‐0.17 [‐1.21, 0.87] |
| 7.2.2 Physical component summary of short‐form 12 (PCS) at 2 years |
1 |
931 |
Mean Difference (IV, Random, 95% CI) |
0.88 [‐0.34, 2.10] |
| 7.2.3 Mental component summary of short‐form 12 (MCS) at baseline |
1 |
1288 |
Mean Difference (IV, Random, 95% CI) |
‐0.06 [‐1.42, 1.30] |
| 7.2.4 Mental component summary of short‐form 12 (MCS) at 2 years |
1 |
931 |
Mean Difference (IV, Random, 95% CI) |
0.81 [‐0.65, 2.27] |
| 7.2.5 EuroQol questionnaire visual analogue scale (EQ‐5D VAS) (1‐100) at baseline |
1 |
1288 |
Mean Difference (IV, Random, 95% CI) |
0.69 [‐0.98, 2.36] |
| 7.2.6 EuroQol questionnaire visual analogue scale (EQ‐5D VAS) (1‐100) at 2 years |
1 |
1010 |
Mean Difference (IV, Random, 95% CI) |
2.08 [0.18, 3.98] |
| 7.2.7 Spielberger State‐Trait Anxiety Inventory (STAI‐6) at baseline |
1 |
1288 |
Mean Difference (IV, Random, 95% CI) |
‐0.48 [‐1.63, 0.67] |
| 7.2.8 Spielberger State‐Trait Anxiety Inventory (STAI‐6) at 2 years |
1 |
931 |
Mean Difference (IV, Random, 95% CI) |
‐0.75 [‐1.99, 0.49] |
| 7.2.9 Impact of event scale (IES) total at baseline |
1 |
1288 |
Mean Difference (IV, Random, 95% CI) |
0.03 [‐0.88, 0.94] |
| 7.2.10 Anxiety ‐ at baseline |
1 |
4037 |
Mean Difference (IV, Random, 95% CI) |
‐0.07 [‐0.11, ‐0.03] |
| 7.2.11 Impact of event scale (IES) total at 2 years |
1 |
931 |
Mean Difference (IV, Random, 95% CI) |
‐0.31 [‐1.30, 0.68] |
| 7.2.12 Anxiety ‐ at 10‐27 months |
1 |
4037 |
Mean Difference (IV, Random, 95% CI) |
‐0.36 [‐0.57, ‐0.15] |
| 7.2.13 Anxiety (0‐18) at round 1 to 2 |
1 |
3352 |
Mean Difference (IV, Random, 95% CI) |
‐0.13 [‐0.33, 0.07] |
| 7.2.14 Anxiety (0‐18) at round 1 to 5 |
1 |
3185 |
Mean Difference (IV, Random, 95% CI) |
‐0.51 [‐0.76, ‐0.26] |
| 7.2.15 Depression ‐ at baseline |
1 |
4037 |
Mean Difference (IV, Random, 95% CI) |
‐0.06 [‐0.10, ‐0.02] |
| 7.2.16 Depression ‐ at 10‐27 months |
1 |
4037 |
Mean Difference (IV, Random, 95% CI) |
‐0.24 [‐0.40, ‐0.08] |
| 7.2.17 Behaviour (0‐21) at round 1 to 2 |
1 |
3337 |
Mean Difference (IV, Random, 95% CI) |
‐0.21 [‐0.42, 0.00] |
| 7.2.18 Behaviour (0‐21) at round 1 to 5 |
1 |
3180 |
Mean Difference (IV, Random, 95% CI) |
‐0.60 [‐0.88, ‐0.32] |
| 7.2.19 Dejection (0‐18) at round 1 to 2 |
1 |
3377 |
Mean Difference (IV, Random, 95% CI) |
‐0.15 [‐0.36, 0.06] |
| 7.2.20 Dejection (0‐18) at round 1 to 5 |
1 |
3195 |
Mean Difference (IV, Random, 95% CI) |
‐0.58 [‐0.82, ‐0.34] |
| 7.2.21 Negative impact on sleep (0‐12) round 1 to 2 |
1 |
3389 |
Mean Difference (IV, Random, 95% CI) |
‐0.14 [‐0.32, 0.04] |
| 7.2.22 Negative impact on sleep (0‐12) round 1 to 5 |
1 |
3198 |
Mean Difference (IV, Random, 95% CI) |
‐0.70 [‐0.95, ‐0.45] |
| 7.3 SF‐36v2: PCS by different components at baseline and at 6 months |
1 |
|
Mean Difference (IV, Random, 95% CI) |
Subtotals only |
| 7.3.1 Negative at baseline |
1 |
1381 |
Mean Difference (IV, Random, 95% CI) |
‐1.07 [‐2.09, ‐0.05] |
| 7.3.2 Negative at 6 months |
1 |
1019 |
Mean Difference (IV, Random, 95% CI) |
‐0.11 [‐1.38, 1.16] |
| 7.3.3 SIFs at baseline |
1 |
344 |
Mean Difference (IV, Random, 95% CI) |
0.16 [‐2.45, 2.77] |
| 7.3.4 SIFs at 6 months |
1 |
226 |
Mean Difference (IV, Random, 95% CI) |
‐1.25 [‐4.26, 1.76] |
| 7.3.5 False positive at baseline |
1 |
1024 |
Mean Difference (IV, Random, 95% CI) |
‐0.72 [‐1.98, 0.54] |
| 7.3.6 False positive at 6 months |
1 |
703 |
Mean Difference (IV, Random, 95% CI) |
‐0.78 [‐2.42, 0.86] |
| 7.3.7 True positive at baseline |
1 |
63 |
Mean Difference (IV, Random, 95% CI) |
‐1.94 [‐7.33, 3.45] |
| 7.3.8 True positive at 6 months |
1 |
42 |
Mean Difference (IV, Random, 95% CI) |
‐0.20 [‐7.32, 6.92] |
| 7.4 SF‐36v2: MCS by different components at baseline and 6 months |
1 |
|
Mean Difference (IV, Random, 95% CI) |
Subtotals only |
| 7.4.1 Negative at baseline |
1 |
1381 |
Mean Difference (IV, Random, 95% CI) |
‐0.85 [‐1.97, 0.27] |
| 7.4.2 Negative at 6 months |
1 |
1019 |
Mean Difference (IV, Random, 95% CI) |
‐0.15 [‐1.52, 1.22] |
| 7.4.3 SIFs at baseline |
1 |
344 |
Mean Difference (IV, Random, 95% CI) |
0.63 [‐1.94, 3.20] |
| 7.4.4 SIFs at 6 months |
1 |
226 |
Mean Difference (IV, Random, 95% CI) |
0.73 [‐2.27, 3.73] |
| 7.4.5 False positive at baseline |
1 |
1024 |
Mean Difference (IV, Random, 95% CI) |
‐0.19 [‐1.43, 1.05] |
| 7.4.6 False positive at 6 months |
1 |
703 |
Mean Difference (IV, Random, 95% CI) |
‐1.02 [‐2.67, 0.63] |
| 7.4.7 True positive at baseline |
1 |
63 |
Mean Difference (IV, Random, 95% CI) |
‐1.74 [‐6.66, 3.18] |
| 7.4.8 True positive at 6 months |
1 |
42 |
Mean Difference (IV, Random, 95% CI) |
0.08 [‐8.19, 8.35] |
| 7.5 Anxiety by different results at 1 and 6 months |
1 |
|
Mean Difference (IV, Random, 95% CI) |
Subtotals only |
| 7.5.1 Negative at 1 month |
1 |
1162 |
Mean Difference (IV, Random, 95% CI) |
‐0.26 [‐1.79, 1.27] |
| 7.5.2 Negative at 6 months |
1 |
1019 |
Mean Difference (IV, Random, 95% CI) |
‐0.33 [‐1.91, 1.25] |
| 7.5.3 SIFs at 1 month |
1 |
272 |
Mean Difference (IV, Random, 95% CI) |
‐0.06 [‐3.52, 3.40] |
| 7.5.4 SIFs at 6 months |
1 |
226 |
Mean Difference (IV, Random, 95% CI) |
‐0.60 [‐4.26, 3.06] |
| 7.5.5 False positive at 1 month |
1 |
835 |
Mean Difference (IV, Random, 95% CI) |
1.77 [‐0.04, 3.58] |
| 7.5.6 False positive at 6 months |
1 |
703 |
Mean Difference (IV, Random, 95% CI) |
1.31 [‐0.61, 3.23] |
| 7.5.7 True positive at 1 month |
1 |
48 |
Mean Difference (IV, Random, 95% CI) |
1.63 [‐6.31, 9.57] |
| 7.5.8 True positive at 6 months |
1 |
42 |
Mean Difference (IV, Random, 95% CI) |
‐2.69 [‐11.69, 6.31] |
