Comparison 8. Secondary outcome: lung cancer by stages at different time points.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
8.1 baseline	5		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
8.1.1 stage 1 (A+B)	5	64092	Risk Ratio (M‐H, Random, 95% CI)	2.41 [1.86, 3.12]
8.1.2 stage 2 (A+B)	5	64092	Risk Ratio (M‐H, Random, 95% CI)	1.88 [0.99, 3.58]
8.1.3 stage 3 (A+B)	5	64092	Risk Ratio (M‐H, Random, 95% CI)	4.28 [1.06, 17.27]
8.1.4 stage 4	5	64092	Risk Ratio (M‐H, Random, 95% CI)	1.05 [0.70, 1.55]
8.1.5 SCLC ‐ limited	1	4104	Risk Ratio (M‐H, Random, 95% CI)	Not estimable
8.1.6 SCLC ‐ extensive	1	4104	Risk Ratio (M‐H, Random, 95% CI)	19.00 [1.11, 326.23]
8.1.7 unknown	2	56773	Risk Ratio (M‐H, Random, 95% CI)	0.99 [0.31, 3.13]
8.2 at 1 year	3		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
8.2.1 stage 1 (A+B)	3	60877	Risk Ratio (M‐H, Random, 95% CI)	2.57 [1.24, 5.32]
8.2.2 stage 2 (A+B)	3	60877	Risk Ratio (M‐H, Random, 95% CI)	1.39 [0.68, 2.84]
8.2.3 stage 3 (A+B)	3	60877	Risk Ratio (M‐H, Random, 95% CI)	1.22 [0.76, 1.95]
8.2.4 stage 4	3	60877	Risk Ratio (M‐H, Random, 95% CI)	0.48 [0.30, 0.77]
8.2.5 SCLC ‐ limited	1	4104	Risk Ratio (M‐H, Random, 95% CI)	1.00 [0.06, 15.98]
8.2.6 SCLC ‐ extensive	1	4104	Risk Ratio (M‐H, Random, 95% CI)	3.00 [0.12, 73.60]
8.2.7 unknown	2	56773	Risk Ratio (M‐H, Random, 95% CI)	1.35 [0.17, 10.75]
8.3 At year 2	2		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
8.3.1 stage 1 (A+B)	2	57559	Risk Ratio (M‐H, Random, 95% CI)	3.53 [1.66, 7.53]
8.3.2 stage 2 (A+B)	2	57559	Risk Ratio (M‐H, Random, 95% CI)	1.08 [0.49, 2.37]
8.3.3 stage 3 (A+B)	2	57559	Risk Ratio (M‐H, Random, 95% CI)	0.92 [0.59, 1.44]
8.3.4 stage 4	2	57559	Risk Ratio (M‐H, Random, 95% CI)	0.80 [0.52, 1.24]
8.3.5 SCLC ‐ limited	1	4104	Risk Ratio (M‐H, Random, 95% CI)	Not estimable
8.3.6 SCLC ‐ extensive	1	4104	Risk Ratio (M‐H, Random, 95% CI)	0.14 [0.01, 2.76]
8.3.7 unknown	1	53455	Risk Ratio (M‐H, Random, 95% CI)	7.00 [0.86, 56.91]
8.4 5 to < 10 years	4		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
8.4.1 stage 1 (A+B)	4	13676	Risk Ratio (M‐H, Random, 95% CI)	2.26 [1.43, 3.57]
8.4.2 stage 2 (A+B)	4	13676	Risk Ratio (M‐H, Random, 95% CI)	0.78 [0.37, 1.66]
8.4.3 stage 3 (A+B)	4	13676	Risk Ratio (M‐H, Random, 95% CI)	0.84 [0.47, 1.49]
8.4.4 4	4	13676	Risk Ratio (M‐H, Random, 95% CI)	0.55 [0.34, 0.91]
8.4.5 unknown	4	13676	Risk Ratio (M‐H, Random, 95% CI)	0.67 [0.41, 1.12]
8.5 ≥ 10 years	4		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
8.5.1 stage 1 (A+B)	4	64864	Risk Ratio (M‐H, Random, 95% CI)	2.57 [1.36, 4.84]
8.5.2 stage 2 (A+B)	4	64864	Risk Ratio (M‐H, Random, 95% CI)	0.94 [0.76, 1.17]
8.5.3 stage 3 (A+B)	4	64864	Risk Ratio (M‐H, Random, 95% CI)	1.23 [0.79, 1.93]
8.5.4 stage 4	4	64864	Risk Ratio (M‐H, Random, 95% CI)	0.77 [0.69, 0.86]
8.5.5 unknown	3	60765	Risk Ratio (M‐H, Random, 95% CI)	0.67 [0.45, 0.99]