Study	Reason for exclusion
Bradley 2021	Irrelevant intervention ‐ lung health check versus usual care
Brodersen 2014	Irrelevant trial design
Dawson 2020	Irrelevant trial design
de‐Torres 2021	Duplicate
Favre 2003	Irrelevant trial design
Fink 2012	Irrelevant trial design
Garg 2002	Irrelevant outcomes ‐ feasibility of conducting a RCT for lung cancer screening among subjects with varying degrees of lung cancer risk
Goulart 2013	Irrelevant trial design
Guldbrandt 2015	Irrelevant patient population
Hassannezhad 2018	Irrelevant trial design
Henschke 2000	Irrelevant trial design
Henschke 2002	Irrelevant trial design
Henschke 2015	Irrelevant trial design
Horeweg 2013	Irrelevant trial design
ISRCTN42704678	Irrelevant intervention ‐ lung health check versus usual care
Kramer 2011	Irrelevant trial design
Kulaga 2007	Irrelevant trial design
Marcus 2006	Irrelevant intervention ‐ sputum cytology and CXR versus usual care
NCT02431962	Irrelevant trial design
Park 2022	Irrelevant outcome ‐ to evaluate the effects of computer‐aided diagnosis (CAD) on inter‐reader agreement in Lung Imaging Reporting and Data System (Lung‐RADS) categorisation
Robbins 2019	Irrelevant trial design
Schabath 2019	Irrelevant trial design
Schreuder 2021	Irrelevant trial design
Spiro 2019	Irrelevant intervention ‐ sputum cytology and cytometry versus usual care
Strauss 2012	Irrelevant trial design
Strauss 2015	Irrelevant trial design
Sullivan 2019	Irrelevant intervention‐ serum biomarker versus usual care
Sullivan 2021	Irrelevant intervention ‐ serum biomarker versus usual care
Yang 2008	Irrelevant intervention ‐ LDCT and serum biomarker versus usual care
Yip 2013	Irrelevant trial design

CXR: chest x‐ray; LDCT: low‐dose computed tomography; RCT: randomised controlled trial