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. 2022 Aug 3;2022(8):CD013829. doi: 10.1002/14651858.CD013829.pub2

Yang 2018.

Study name AME Thoracic Surgery Collaborative Group
Methods Trial design: phase 3 RCT 
Duration of follow‐up: not published
Number of trial locations: 1
Trial registration: not reported
Participants Baseline characteristics
Number of participants: LDCT arm (3512); control arm (3145)
Age: mean age LDCT arm (60 years old); control arm (60 years old)
Sex: LDCT arm (1625 males, 1887 females); control arm (1489 males, 1656 females)
Smoking status: LDCT arm (729 current, 246 former, 831 passive); control arm (701 current, 202 former, 745 passive)
Performance status: not published
Ethnicity: not published
Environmental exposures: LDCT arm (2144 cooking oil fumes, 34 asbestos, 248 dust, 57 radiation exposure); control arm (1924 cooking oil fumes, 24 asbestos, 212 dust, 47 radiation exposure)
Inclusion criteria
  • Asymptomatic residents in selected housing estates

  • Age 45‐70 years old

  • At least one of the following high‐risk factors

    • Current or former smokers who had a history of ≥ 20 pack years, no more than 15 years since quitting

    • Cancer history of any kind in close family members

    • Cancer history of any kind for the participant

    • Occupational exposure to carcinogenic agents (asbestos, dust, or radiation)

    • Long history of passive smoking (> 2 hours every day in homes or indoor workplaces for at least 10 years)

    • Long‐term exposure to cooking oil fumes (history of stir frying, frying, or deep frying > 50 dish years)


Exclusion criteria
  • Previous diagnosis of lung cancer

  • Performance status score > 2

  • CT scan of chest within 12 months or had a diagnosis of any other cancer (including lung cancer) within the past 5 years


Preintervention investigations
  • Nil 

Interventions Intervention characteristics
  • Frequency of scanning: biennial

  • LDCT setting: 140 kVP, 40 mA

  • Duration of screening: 3 rounds of screening (6 years)


Interpretation of scans
  • Volumetric or size criteria: both

  • Use of computer‐assisted diagnostics: not specified 

  • Criteria for significance: any non‐calcified nodule or masses with longest diameter ≥ 4 mm 

  • Prespecified protocol for nodule follow‐up: yes


Comparison
  • Description: no screening

Outcomes Primary outcome
  • Efficiency of LDCT in lung cancer detection in asymptomatic high‐risk population


Secondary outcome
  • Lung cancer‐specific mortality

Starting date 2013
Contact information Baohui Han; xkyyhan@gmail.com
Notes Conflicts of interest: nil disclosed 

CT: computed tomography; CXR: chest x‐ray; LDCT: low‐dose computed tomography; RCT: randomised controlled trial