Yang 2018.

Study name	AME Thoracic Surgery Collaborative Group
Methods	Trial design: phase 3 RCT  Duration of follow‐up: not published Number of trial locations: 1 Trial registration: not reported
Participants	Baseline characteristics Number of participants: LDCT arm (3512); control arm (3145) Age: mean age LDCT arm (60 years old); control arm (60 years old) Sex: LDCT arm (1625 males, 1887 females); control arm (1489 males, 1656 females) Smoking status: LDCT arm (729 current, 246 former, 831 passive); control arm (701 current, 202 former, 745 passive) Performance status: not published Ethnicity: not published Environmental exposures: LDCT arm (2144 cooking oil fumes, 34 asbestos, 248 dust, 57 radiation exposure); control arm (1924 cooking oil fumes, 24 asbestos, 212 dust, 47 radiation exposure) Inclusion criteria Asymptomatic residents in selected housing estates Age 45‐70 years old At least one of the following high‐risk factors Current or former smokers who had a history of ≥ 20 pack years, no more than 15 years since quitting Cancer history of any kind in close family members Cancer history of any kind for the participant Occupational exposure to carcinogenic agents (asbestos, dust, or radiation) Long history of passive smoking (> 2 hours every day in homes or indoor workplaces for at least 10 years) Long‐term exposure to cooking oil fumes (history of stir frying, frying, or deep frying > 50 dish years) Exclusion criteria Previous diagnosis of lung cancer Performance status score > 2 CT scan of chest within 12 months or had a diagnosis of any other cancer (including lung cancer) within the past 5 years Preintervention investigations Nil
Interventions	Intervention characteristics Frequency of scanning: biennial LDCT setting: 140 kVP, 40 mA Duration of screening: 3 rounds of screening (6 years) Interpretation of scans Volumetric or size criteria: both Use of computer‐assisted diagnostics: not specified  Criteria for significance: any non‐calcified nodule or masses with longest diameter ≥ 4 mm  Prespecified protocol for nodule follow‐up: yes Comparison Description: no screening
Outcomes	Primary outcome Efficiency of LDCT in lung cancer detection in asymptomatic high‐risk population Secondary outcome Lung cancer‐specific mortality
Starting date	2013
Contact information	Baohui Han; xkyyhan@gmail.com
Notes	Conflicts of interest: nil disclosed

CT: computed tomography; CXR: chest x‐ray; LDCT: low‐dose computed tomography; RCT: randomised controlled trial