Table 1.

The predicted effect of Spike protein single mutations of Omicron variants on pathogenicity by using PredictSNP tool.

Wild residue	Position	Target residue	Predicted type	Predict SNP accuracy	Mutation present in
T	19	I	NEUTRAL	65%	BA.2
A	27	S	NEUTRAL	82%	BA.2
A	67	V	NEUTRAL	73%	BA.1, BA.1.1
T	95	I	DELETERIOUS	60%	BA.1, BA.1.1, BA.3
G	142	D	NEUTRAL	74%	BA.1, BA.1.1, BA.3
Y	144	D	NEUTRAL	74%	BA.1, BA.1.1
Y	145	D	NEUTRAL	63%	BA.1, BA.1.1
N	211	I	DELETERIOUS	60%	BA.1, BA.1.1, BA.3
L	212	V	NEUTRAL	82%	BA.1, BA.1.1, BA.3
V	213	R	DELETERIOUS	65%	BA.1, BA.1.1, BA.3
R	214	E	NEUTRAL	75%	BA.1.1
G	339	D	NEUTRAL	73%	BA.1, BA.1.1, BA.2, BA.3
R	346	K	NEUTRAL	82%	BA.1.1
S	371	L	NEUTRAL	82%	BA.1, BA.1.1, BA.3
S	371	F	NEUTRAL	73%	BA.2
S	373	P	NEUTRAL	82%	BA.1, BA.1.1, BA.2, BA.3
S	375	F	NEUTRAL	75%	BA.1, BA.1.1, BA.2, BA.3
T	376	A	NEUTRAL	65%	BA.2
D	405	N	NEUTRAL	62%	BA.2, BA.3
R	408	S	NEUTRAL	73%	BA.2
K	417	N	NEUTRAL	73%	BA.1, BA.1.1, BA.2, BA.3
N	440	K	NEUTRAL	73%	BA.1, BA.1.1, BA.2, BA.3
G	446	S	NEUTRAL	82%	BA.1, BA.1.1, BA.3
S	477	N	NEUTRAL	82%	BA.1, BA.1.1, BA.2, BA.3
T	478	K	NEUTRAL	63%	BA.1, BA.1.1, BA.2, BA.3
E	484	A	NEUTRAL	82%	BA.1, BA.1.1, BA.2, BA.3
Q	493	R	NEUTRAL	75%	BA.1, BA.1.1, BA.2, BA.3
G	496	S	NEUTRAL	63%	BA.1, BA.1.1
Q	498	R	NEUTRAL	68%	BA.1, BA.1.1, BA.2, BA.3
N	501	Y	NEUTRAL	60%	BA.1, BA.1.1, BA.2, BA.3
Y	505	H	DELETERIOUS	60%	BA.1, BA.1.1, BA.2, BA.3
T	547	K	NEUTRAL	82%	BA.1, BA.1.1
D	614	G	NEUTRAL	82%	BA.1, BA.1.1, BA.2, BA.3
H	655	Y	NEUTRAL	73%	BA.1, BA.1.1, BA.2, BA.3
N	679	H	NEUTRAL	82%	BA.1, BA.1.1, BA.2, BA.3
N	679	K	NEUTRAL	82%	BA.3
P	681	K	NEUTRAL	82%	BA.1, BA.1.1, BA.2, BA.3
N	764	K	DELETERIOUS	71%	BA.1, BA.1.1, BA.2, BA.3
D	796	Y	NEUTRAL	75%	BA.1, BA.1.1, BA.2, BA.3
N	856	K	DELETERIOUS	75%	BA.1, BA.1.1
Q	954	H	NEUTRAL	73%	BA.1, BA.1.1, BA.2, BA.3
N	969	K	DELETERIOUS	54%	BA.1, BA.1.1, BA.2, BA.3
L	981	F	NEUTRAL	82%	BA.1, BA.1.1

Note: Predicted deleterious mutation marked as bold.