TABLE A2.

Sensitivity analyses: adjusted odds ratios (ORs) for hospitalization and intensive care unit (ICU) admission/mechanical ventilation

Characteristic	Hospitalization, OR (95% CI)	ICU admission/mechanical ventilation, OR (95% CI)
Adjusted for statins
Testosterone ≤90 days	0.98 (0.75, 1.28)	0.69 (0.38, 1.27)
Testosterone ≤120 days	0.94 (0.73, 1.21)	0.64 (0.37, 1.12)
Restricted to large hospital networks
Testosterone ≤90 days	0.92 (0.70, 1.20)	0.67 (0.37, 1.23)
Testosterone ≤120 days	0.87 (0.68, 1.13)	0.88 (0.40, 1.94)

Note: Each case–control study was matched on sex, race, age group, and each of the following medical conditions: COPD (ICD‐10‐CM = I27.8x, I27.9, J41.x‐J47.x, J60.x‐J67.x, J68.4, J70.1, J70.3), obesity (ICD‐10‐CM = E66.x), atherosclerotic cardiovascular disease (ICD‐10‐CM = I25.10), angina (ICD‐10‐CM = I20.x), diabetes (ICD‐10‐CM = E11.x‐E13.x), hypertension (ICD‐10‐CM = I10.x‐I15.x), and hyperlipidemia (ICD‐10‐CM = E78.x, E88.1). Multivariable analyses were adjusted for all unmatched variables including: ethnicity, region, and Elixhauser score. Second case–control studies were also adjusted for dexamethasone and remdesivir. Cases were defined as patients who were admitted to the ICU (had one encounter during the hospitalization that was coded as “critical care unit [CCU]/ICU”) or received mechanical ventilation (ICD‐10‐PCS: 5A09357, 5A09358, 5A09359, 5A0935A, 5A0935B, 5A0935Z, 5A09457, 5A09458, 5A09459, 5A0945A, 5A0945B, 5A0945Z, 5A09557, 5A09558, 5A09559, 5A0955A, 5A0955B, 5A0955Z, 5A19054, 5A1935Z, 5A1945Z, 5A1955Z; CPT: 94002, 94003, 94004).

Abbreviation: CI, confidence interval.