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. 2022 May 13:10.1111/hae.14586. Online ahead of print. doi: 10.1111/hae.14586

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© 2022 The Authors. Haemophilia published by John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Observed bleeding risk according to haemophilia severity and prophylaxis before vaccination. Data was derived from part B of the study. Compare Table 3 for absolute patient numbers per group. The risk is provided by its point estimate (number of observed bleeds / number vaccinations per group, in percentage) and the Wilson 95% confidence interval. Prophylaxis before vaccination (“yes”) was defined as FVIII SHL or EHL or FIX concentrate within the last 48 h, or FIX EHL concentrate within the last 96 h, or emicizumab