TABLE 1.
Comparison of baseline characteristics between hospitalised patients diagnosed with cryptococcosis within 3 months of the most recent COVID‐19 diagnosis and hospitalised patients without a diagnosis of cryptococcosis within 3 months of COVID‐19 diagnosis
| Variable | Cryptococcosis following COVID‐19 (n = 65) | COVID‐19 without cryptococcosis (n = 212,414) | p value |
|---|---|---|---|
| Age at index event (years), mean (SD) | 56.8 (14.5) | 56 (22.4) | .7692 |
| Male sex | 52 (80) | 108,802 (51) | <.0001 |
| BMI (kg/m2), mean (SD) | 26.8 (6.93) | 29.3 (7.69) | 1036 |
| Race | |||
| White | 41 (63) | 144,234 (68) | .4047 |
| Black or African American | 17 (26) | 41,868 (20) | .1917 |
| Asian | 0 (0) | 410,916 (2) | .2571 |
| Unknown race | 10 (15) | 20,982 (10) | .1368 |
| Ethnicity | |||
| Hispanic or Latino | 14 (22) | 29,260 (14) | .0694 |
| Non‐Hispanic | 48 (74) | 161,555 (76) | .6763 |
| Underlying comorbidities | |||
| HIV | 21 (32) | 3461 (2) | <.0001 |
| Transplanted organs or tissues | 18 (28) | 5659 (3) | <.0001 |
| Neoplasm | 17 (26) | 46,629 (22) | .4132 |
| Immunodeficiency with predominantly antibody defects | 10 (15) | 589 (<1) | <.0001 |
| Combined immunodeficiencies | 0 (0) | 67 (<1) | .8861 |
| Common variable immunodeficiency | 0 (0) | 137 (<1) | .8377 |
| Other immunodeficiencies | 21 (32) | 5592 (3) | <.0001 |
| Sarcoidosis | 10 (15) | 981 (<1) | <.0001 |
| Systemic connective tissue disorders | 10 (15) | 8378 (4) | <.0001 |
| Rheumatoid arthritis | 10 (15) | 596 (<1) | <.0001 |
| Non‐infective enteritis and colitis | 10 (15) | 10,007 (5) | <.0001 |
| Hepatic fibrosis and cirrhosis | 10 (15) | 5351 (3) | <.0001 |
| Type 2 diabetes mellitus | 27 (42) | 64,126 (30) | .0463 |
| Heart failure | 18 (28) | 36,674 (17) | .0262 |
| Malnutrition | 17 (26) | 11,436 (5) | <.0001 |
| Chronic kidney disease | 26 (40) | 51,074 (24) | .0026 |
| Laboratory values | |||
| Leukocytes (K/μl), mean (SD) | 9.18 (6.9) | 9.11 (21.8) | .9818 |
| Lymphocytes (K/μl), mean (SD) | 1.97 (4.31) | 3.68 (10.5) | .3472 |
| CD4 cells (cells/μl), mean (SD) | 73 (68.9) | 299 (316) | .0242 |
| AST (units/L), mean (SD) | 80.3 (235) | 58.2 (256) | .5582 |
| ALT (units/L), mean (SD) | 85.1 (393) | 45.4 (157) | .0769 |
| Alkaline phosphatase (units/L), mean (SD) | 139 (141) | 101 (101) | .0097 |
| Serum creatinine (mg/dl) | 1.61 (1.37) | 1.36 (1.79) | .2923 |
| Albumin (mg/dl), mean (SD) | 3.02 (0.767) | 3.46 (0.665) | <.0001 |
| Haemoglobin A1C (%), mean (SD) | 7.34 (2.46) | 7.29 (2.36) | 0.9404 |
| Ferritin (ng/ml), mean (SD) | 5253 (17950) | 941 (2344) | <.0001 |
| C‐reactive protein (mg/dl), mean (SD) | 81.7 (84.3) | 79.4 (82.6) | .8972 |
| Lactate dehydrogenase (units/L) | 1006 (1798) | 433 (501) | <.0001 |
Note: Data are presented as n (%) unless otherwise noted.
Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; COVID‐19, coronavirus disease 2019; SD, standard deviation.