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. 2022 Jul 31;14(1):2104087. doi: 10.1080/19490976.2022.2104087

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© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — CD1d-deficiency and loss of iNKT cells does not alter microbiota composition. (a, b) 16S bacterial rRNA sequencing was used to define the microbiota profiles of CD1d^+/+ and CD1d^−/− littermate mice (n = 6 mice per group). These groups were separated by principal coordinates PCo1 and PCo2, collectively explaining 58.8% of the total similarity between samples, based on Bray-Curtis distances (a). Permutational multivariate analysis of the variance using Adonis (b). Data shows R² (effect size) and adjusted p values for genotype, sex, caging and parental group. (c, d) 16S bacterial rRNA sequencing was used to define the microbiota profiles of CD1d^+/+, CD1d^+/− and CD1d^−/− littermate mice (n = 8 mice per group) obtained from 2 consecutive litters from heterozygous harem breeding (1 male + 3 females). These groups were separated by principal coordinates PCo1 and PCo2, collectively explaining 29.9% of the total similarity between samples, based on Bray-Curtis distances (c). Permutational multivariate analysis of the variance using Adonis (d). Data shows R² (effect size) and adjusted p values for genotype, sex, caging and parental group. (e, f) Combined Bray-Curtis PCoA of the two experiments (e) and Adonis (f) shows R² (effect size) and adjusted p values for genotype, sex, caging, parental group and sampling/experiment.