FIGURE 8.

Impact of viral mutation on antibody recognition. The cartoon on the left depicts the restricted binding sites for neutralizing antibodies (purple), that either interfere directly with binding or fusion machinery, or may allosterically interfere with binding/fusion. Conversely, non‐neutralizing Fc‐functional antibodies (yellow) may bind to the entire surface of the spike. Yet, with the incorporation of mutations, in Variations of Concern, changes that may impede neutralizing antibody binding may disrupt a few, but only a fraction of non‐neutralizing antibodies