Table 2.

Clinical indexes of Covid‐19 patients over the course of remdesivir therapy

Clinical index	Reference range	Gender	Days of remdesivir therapy			p
			1st	3rd	5th
WBC	4.5–11 (×10*3/micL)	M F	5.30 ± 1.84 4.63 ± 1.53	7.41 ± 2.25 6.23 ± 1.84	6.94 ± 2.28 6.05 ± 1.06	0.006 0.001
ESR	Up to 15 (mm/h)	M F	41.27 ± 26.44 44.50 ± 20.58	41.01 ± 29.78 34.81 ± 17.48	22.0 ± 12.66 30.60 ± 14.85	0.003 0.001
CRP	Up to 6 (mg/L)	M F	27.11 ± 26.99 22.34 ± 18.54	16.57 ± 15.53 14.58 ± 15.04	10.88 ± 11.91 10.49 ± 10.66	0.001 0.002
ALT	Up to 40 (U/L)	M F	32.73 ± 19.60 43.10 ± 23.68	51.60 ± 31.05 49.21 ± 28.69	61.22 ± 31.87 55.30 ± 30.07	0.001 0.001
AST	Up to 37 (U/L)	M F	37.86 ± 8.77 43.51 ± 15.54	47.86 ± 11.35 55.50 ± 18.59	51.93 ± 15.76 60.95 ± 18.98	0.001 0.001
ALP	65–305 (U/L)	M F	198.94 ± 65.25 234.60 ± 115.08	134.93 ± 43.47 152.10 ± 58.75	126.40 ± 27.75 128.20 ± 58.41	0.001 0.001
Sodium	135–145 (mEq/L)	M F	135.67 ± 3.31 137.80 ± 4.12	138.47 ± 3.74 137.30 ± 2.72	137.87 ± 3.81 138.80 ± 1.98	0.026 0.195
Potassium	3.5–5.5 (mEq/L)	M F	4.07 ± 0.19 3.90 ± 0.37	3.91 ± 0.17 3.69 ± 0.29	3.90 ± 0.16 3.63 ± 0.21	0.017 0.004
BUN	14–45 (mg/dl)	M F	29.67 ± 12.52 27.99 ± 9.78	40.33 ± 14.48 36.60 ± 9.12	41.01 ± 6.47 38.31 ± 5.98	0.001 0.001
Creatinine	0.7–1.4 (mg/dl)	M F	1.06 ± 0.25 0.86 ± 0.15	1.05 ± 0.21 0.83 ± 0.17	1.04 ± 0.20 1.0 ± 0.16	0.848 0.001
eGFR	≥60 ml/min/1.73 m2	M F	81.07 ± 22.18 79.31 ± 18.88	79.53 ± 19.74 75.90 ± 17.30	78.73 ± 17.19 62.05 ± 14.37	0.907 0.001
Hear rate	60–100 beats/min	M F	81.13 ± 12.19 77.30 ± 10.30	62.33 ± 12.14 60.85 ± 6.23	58.13 ± 14.06 51.15 ± 4.34	0.001 0.001

Abbreviations: ALT, alanine transaminase; ALP, alkaline phosphatase; AST, aspartate aminotransferase; BUN, blood urea nitrogen; Covid‐19, corona disease 2019; CRP, C‐reactive protein; eGFR, estimated glomerular filtration rate; ESR, erythrocyte sedimentation rate; F, female; M, male; WBC, white blood cell.

^*Continues data are presented as mean ± SD.