Table 3.

Effects of gender and age on remdesivir AEs assessed by LMM analysis

Variables	Mean ± SE	Gender	Age
WBC	Male = 6.57 ± 0.33	β = 1.03	β = −0.02
	Female = 5.63 ± 0.30	p = 0.029	p = 0.023
ESR	Male = 29.83 ± 5.52	β = −2.69	β = −0.13
	Female = 40.30 ± 4.81	p = 0.629	p = 0.404
CRP	Male = 17.80 ± 2.84	β = 1.54	β = −0.062
	Female = 16.26 ± 2.65	p = 0.770	p = 0.676
ALT	Male = 48.09 ± 6.81	β = −1.42	β = 0.09
	Female = 49.51 ± 6.08	p = 0.882	p = 0.735
AST	Male = 46.29 ± 3.49	β = −7.60	β = 0.05
	Female = 53.01 ± 3.16	p = 0.143	p = 0.708
ALP	Male = 151.47 ± 15.73	β = −21.62	β = 0.43
	Female = 173.09 ± 13.03	p = 0.310	p = 0.478
Sodium	Male = 137.78 ± 0.56	β = 0.15	β = −0.06
	Female = 137.64 ± 0.49	p = 0.847	p = 0.026
Potassium	Male = 3.90 ± 0.04	β = 0.12	β = 0.001
	Female = 3.78 ± 0.03	p = 0.060	p = 0.597
BUN	Male = 35.52 ± 1.54	β = 0.73	β = 0.23
	Female = 34.78 ± 1.46	p = 0.623	p = 0.001
Creatinine	Male = 1.04 ± 0.04	β = 0.15	β = −0.02
	Female = 0.91 ± 0.03	p = 0.009	p = 0.460
eGFR	Male = 84.04 ± 4.08	β = 10.79	β = −0.16
	Female = 71.15 ± 3.66	p = 0.051	p = 0.294
Heart rate	Male = 68.55 ± 1.76	β = 6.22	β = − 0.29
	Female = 62.10 ± 1.53	p = 0.015	p = 0.001

Abbreviations: AE, adverse effect; ALT, alanine transaminase; ALP, alkaline phosphatase; AST, aspartate aminotransferase; BUN, blood urea nitrogen; CRP, C‐reactive protein; eGFR, estimated glomerular filtration rate; ESR, erythrocyte sedimentation rate; LMM, linear mixed model; WBC, white blood cell.