Table 2. Advantages and Disadvantages of the polymers involved in fabrication of hydrogel scaffolds for skin tissue regeneration .

Name of the Polymer	Advantages	Disadvantages	Reference
Polyvinyl alcohol	• Shown ideal biocompatibility, biodegradability, controlled rate of release. • Minimal cytotoxicity	• Poor cell adhesive characteristics. • Weak hydrogel durability at high temperature.	34
Polyvinylpyrrolidone	• Enhanced the permeation potential and biocompatibility of the incorporated therapeutical moieties.	• Poor mechanical characteristics. • Minimal swelling capacity.	35
Poloxamer	• Excellent biocompatibility, high solubilisation characteristics (in case of hydrophobic drugs).	• Poor biodegradability and mechanical characteristics.	36
Dextran	• Ideal bioadhesive property. • Promoted sustained rate of protein or drug release.	• High cost and faster degradability.	37
Fibrin	• Minimal risk of immunogenic response. • Controlled rate of degradation.	• Low mechanical stiffness.	38
Alginate	• Controlled release of therapeutical molecules. • Biomimetic property.	• Faster rate of degradation. • Minimal cellular adhesion.	39