Table 3. Significance of Stem cells loaded hydrogels in skin tissue regeneration .

Formulation	Author	Significance	Reference
dsASCs loaded collagen- PEG fibrin-based bilayer hydrogel.	Natesan et al (2013)	• Isolation of stem cells from the burnt wound site of the patient enhanced the tissue compatibility of these hydrogels.	40
Mesenchymal stem cell spheroids loaded Fibrin hydrogel.	Murphy et al (2017)	• Excellent viscoelastic properties. • Optimal release of mesenchymal stem cells. Enhanced the VEGF (promotes the neovascularization) and PGE2 (modulates both inflammatory and fibrogenesis phase) secretion. • Decreased TNF-α secretion induces fibroblasts to produce proteoglycan and fibronectin in the injured tissues, promoting extracellular matrix formation.	46
ASCs loaded Pluronic F127 hydrogel.	Kaisang et al (2017)	• Ideal biomimetic. • 3D scaffold characteristics. • Increased TGF-β1 secretion contributes to wound healing by inhibiting inflammation, promoting angiogenesis, and collagen synthesis and deposition.	47
Silver sulfadiazine and adipose stem cells loaded fibrin hydrogel.	Banerjee et al (2019)	• Controlled release of silver sulfadiazine and adipose stem cells. • Minimal cytotoxicity.	48
Adipose stem cells loaded polyethylene glycol-fibrin hydrogels.	Burmeister et al (2018)	• Ideal contraction. • Angiogenesis.	49

Abbreviations: dsASCs, debrided skin adipose stem cells; PEG, polyethylene glycol; ASCs, Adipose-derived stem cells.