Table 1. Role of different Signaling pathways in MS .

Signaling pathway	Action	Reference
WNT/Catenin pathway	Release of cytokines by CD4+ Th17 cells.	36
JAK/STAT	Functioning and development of both adaptive and innate immunity.	41
PI3/AKT/mTOR	T-cell activation, proliferation, metabolism and apoptosis.	51
NF-kB	Maturation of immune cells and production of inflammatory mediators.	49