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. 2021 Jul 3;12(3):449–465. doi: 10.34172/apb.2022.049

Table 2. Overview on the antimicrobial activity of functionalized SWCNTs-based nanocomposites in different studies .

Material blend Concentration Species Main findings References
f-SWNTs with functional groups (-OH, -COOH, -NH2) 50-200 µg/mL S. aureus, B. Subtilis, and S. typhimurium SWNTs functionalized with -OH and -COOH functional group showed more microbial inhibition rate (7-log reduction) against selected pathogens, while SWNTs with -NH2 displayed antimicrobial activity only at high concentrations. 46
Silver-SWNTs functionalized with peptides (TP226, TP359, TP557) 5 µg/mL S. aureus The viability of bacteria increased by 4-log in non-treated skin model, whereas treated skin with functionalized silver-SWNTs showed antimicrobial activity only 1-log reduction. 28
Functionalized SWNTs with DNA and lysozyme (LSZ) ~25 mg/L S. aureus, and M. lysodeikticus Layer by layer coating of DNA- and LSZ-SWNTs displayed high antimicrobial activity (with 84% microbial reduction). 29
SWNTs incorporated inside poly(lactic-co-glycolic acid)  < 2% by weight E. coli, and S. epidermidis The metabolic activity of bacteria was considerably decreased (98%) with SWNTs-PLGA, while 15-20% reduction rate observed with pure PLGA. 26
SWNTs-polyvinyl-N-carbazole (PVK) nanocomposite 3 wt.% E. coli, and B. subtilis SWNTs-PVK nanocomposite induced a higher rate of bacterial inactivation (90% for B. subtilis and 94% for E. coli) in the planktonic cells and showed a significant reduction of biofilm formation. 48
SWNTs assembled with poly(L-glutamic acid) (PGA) and poly(L-lysin)(PLL) (layer-by-layer)  < 2% by weight E. coli, and S. epidermidis SWNTs/PGA/PLL showed a higher rate of antimicrobial activity (90%) against selected pathogens than non-treated samples of PGA/PLL (with 20% reduction rate). 26
Oxidized SWNTs with poly(vinyl alcohol) (PVOH) nanocomposite 0-10% (w/w) Pseudomonas aeruginosa The viability of cell deposited on the surface of O-SWNTs-PVOH gradually decreased with increasing in nanotubes loading. 49
SWNTs/porphyrin composite 0.04 mg/mL S. aureus In the presence of visible light, SWNTs/porphyrin induced damage to the cell membrane. 50
Functionalized-SWNTs/ poly(ethylene glycol) (PEG) and poly(ε caprolactone) composites 0.5-1.0 wt.% P. aeruginosa, and S. aureus The proliferation of tested bacteria inhibited by f-SWNT/copolymer complex to a lower extent as compared to pure polymer complex. 51
SWNTs bound with polyamide membranes 0.1-0.2 mg/mL E. coli The complex of nanocomposite inactivated the microbial cells by 60% after 1 h of contact time. 50