Table 1. The concentration of drugs and polymers, solvent mixture, method of preparation, viscosity and conductivity of electrospinning solutions, used for development of formulations .
Components | Formulation | ||||||
G1 | G2 | G3 | G4 | G5 | G6 | G7 | |
PCL (%w/v) | 10 | 10 | 10 | 10 | 10 | 10 | 0 |
PVA (%w/v) | 0 | 0 | 0 | 15 | 15 | 15 | 10 |
PLGA (%w/v) | 0 | 0 | 0 | 0 | 0 | 0 | 20 |
MP/Polymera (%w/w) | 0 | 0 | 0 | 6 | 6 | 6 | 6 |
GNT/Polymerb (%w/w) | 10 | 10 | 10 | 20 | 20 | 20 | 20 |
DCM: DMF | 1:1 | 3:2 | 9:1 | 1:1 | 1:1 | 1:1 | 1:1 |
Viscosity (cP)c | 150 | 160 | 220 | 120 | 120 | 120 | 100 |
Conductivity (µs/m)c | 0.4 | 0.3 | 0.1 | 0.45 | 0.45 | 0.45 | 0.38 |
Method of preparation | Single-layer | Single-layer | Single-layer | Mixed | Sandwich | Core-shell | Mixed |
a The polymer is PCL in case of G4-5 and PLGA in case of G7.
b The polymer is PCL in case of G1-3 and PVA in case of G4-7.
c Measured for organic electrospinning solutions (PCL and PLGA solutions).